SCOPe 2.05: Domain d1uoua2: 1uou A:101-373

Lineage for d1uoua2 (1uou A:101-373)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.27: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain [52417] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 5 strands, order 32145; Rossmann-like

4. Superfamily c.27.1: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain [52418] (2 families)
   automatically mapped to Pfam PF00591

5. Family c.27.1.1: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain [52419] (4 proteins)

6. Protein Thymidine phosphorylase [52420] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [102268] (1 PDB entry)

8. Domain d1uoua2: 1uou A:101-373 [99707]
   Other proteins in same PDB: d1uoua1, d1uoua3
   complexed with cmu

Details for d1uoua2

PDB Entry: 1uou, 2.11 Å

PDB Description: crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor

PDB Compounds: (A:) thymidine phosphorylase

SCOPe Domain Sequences for d1uoua2:

Sequence, based on SEQRES records:

>d1uoua2 c.27.1.1 (A:101-373) Thymidine phosphorylase {Human (Homo sapiens) [TaxId: 9606]}
qlewpeawrqqlvdkhstggvgdkvslvlapalaacgckvpmisgrglghtggtldkles
ipgfnviqspeqmqvlldqagccivgqseqlvpadgilyaardvtatvdslplitasils
kklveglsalvvdvkfggaavfpnqeqarelaktlvgvgaslglrvaaaltamdkplgrc
vghaleveeallcmdgagppdlrdlvttlggallwlsghagtqaqgaarvaaalddgsal
grfermlaaqgvdpglaralcsgspaerrqllp

Sequence, based on observed residues (ATOM records):

>d1uoua2 c.27.1.1 (A:101-373) Thymidine phosphorylase {Human (Homo sapiens) [TaxId: 9606]}
qlewpeawrqqlvdkhstggvgdkvslvlapalaacgckvpmisgrglghtggtldkles
ipgfnviqspeqmqvlldqagccivgqseqlvpadgilyaardvtatvdslplitasils
kklveglsalvvdvkfgavfpnqeqarelaktlvgvgaslglrvaaaltamdkplgrcvg
haleveeallcmdgagppdlrdlvttlggallwlsghagtqaqgaarvaaalddgsalgr
fermlaaqgvdpglaralcsgspaerrqllp

Timeline for d1uoua2:

• d1uoua2 first appeared in SCOP 1.67
  
• d1uoua2 appears in SCOPe 2.04
  
• d1uoua2 appears in SCOPe 2.06
  
• d1uoua2 appears in the current release, SCOPe 2.08