SCOP 1.67: Domain d1udta_: 1udt A:

Lineage for d1udta_ (1udt A:)

1. Root: SCOP 1.67

2. Class a: All alpha proteins [46456] (202 folds)

3. Fold a.125: PDEase [48546] (1 superfamily)
   multihelical; can be divided into three subdomains

4. Superfamily a.125.1: PDEase [48547] (1 family)

5. Family a.125.1.1: PDEase [48548] (4 proteins)
   3',5'-cyclic-nucleotide phosphodiesterase, Pfam 00233

6. Protein cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx [101439] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [101440] (3 PDB entries)

8. Domain d1udta_: 1udt A: [99221]
   complexed with mg, via, zn

Details for d1udta_

PDB Entry: 1udt, 2.3 Å

PDB Description: Crystal structure of Human Phosphodiesterase 5 complexed with Sildenafil(Viagra)

SCOP Domain Sequences for d1udta_:

Sequence, based on SEQRES records:

>d1udta_ a.125.1.1 (A:) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens)}
trelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlc
rwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdld
hrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlkii
kqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqq
riaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvs
edcfplldgcrknrqkwqalaeqq

Sequence, based on observed residues (ATOM records):

>d1udta_ a.125.1.1 (A:) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens)}
trelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlc
rwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdld
hrgvnnsyychsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailatdlal
yikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelvateff
dqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvsedcfplldgcr
knrqkwqalaeqq

Timeline for d1udta_:

• d1udta_ is new in SCOP 1.67
  
• d1udta_ appears in SCOP 1.69
  
• d1udta_ appears in the current release, SCOPe 2.08