SCOPe 2.05: Domain d1s78e1: 1s78 E:1-107

Lineage for d1s78e1 (1s78 E:1-107)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Engineered (including hybrid species) [88533] (61 PDB entries)
   SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # Humanized antibody ! SQ NA # humanized antibody ! SQ NA # engineered antibody

8. Domain d1s78e1: 1s78 E:1-107 [98628]
   Other proteins in same PDB: d1s78a1, d1s78a2, d1s78a3, d1s78a4, d1s78b1, d1s78b2, d1s78b3, d1s78b4, d1s78c2, d1s78d1, d1s78d2, d1s78e2, d1s78f1, d1s78f2
   part of anti-ERBb2 Fab Pertuzumab
   complexed with nag

Details for d1s78e1

PDB Entry: 1s78, 3.25 Å

PDB Description: insights into erbb signaling from the structure of the erbb2- pertuzumab complex

PDB Compounds: (E:) Pertuzumab Fab light chain

SCOPe Domain Sequences for d1s78e1:

Sequence; same for both SEQRES and ATOM records:

>d1s78e1 b.1.1.1 (E:1-107) Immunoglobulin light chain kappa variable domain, VL-kappa {Engineered (including hybrid species)}
diqmtqspsslsasvgdrvtitckasqdvsigvawyqqkpgkapklliysasyrytgvps
rfsgsgsgtdftltisslqpedfatyycqqyyiypytfgqgtkveik

Timeline for d1s78e1:

• d1s78e1 first appeared in SCOP 1.67
  
• d1s78e1 appears in SCOPe 2.04
  
• d1s78e1 appears in SCOPe 2.06
  
• d1s78e1 appears in the current release, SCOPe 2.08