SCOPe 2.03: Domain d1s78c2: 1s78 C:108-214

Lineage for d1s78c2 (1s78 C:108-214)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (147 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d1s78c2: 1s78 C:108-214 [98625]
   Other proteins in same PDB: d1s78a1, d1s78a2, d1s78a3, d1s78a4, d1s78b1, d1s78b2, d1s78b3, d1s78b4, d1s78c1, d1s78d1, d1s78d2, d1s78e1, d1s78f1, d1s78f2
   part of anti-ERBb2 Fab Pertuzumab
   complexed with nag

Details for d1s78c2

PDB Entry: 1s78, 3.25 Å

PDB Description: insights into erbb signaling from the structure of the erbb2- pertuzumab complex

PDB Compounds: (C:) Pertuzumab Fab light chain

SCOPe Domain Sequences for d1s78c2:

Sequence; same for both SEQRES and ATOM records:

>d1s78c2 b.1.1.2 (C:108-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Timeline for d1s78c2:

• d1s78c2 first appeared in SCOP 1.67
  
• d1s78c2 appears in SCOPe 2.02
  
• d1s78c2 appears in SCOPe 2.04
  
• d1s78c2 appears in the current release, SCOPe 2.08