SCOP 1.71: Domain d1s78c1: 1s78 C:1-107

Lineage for d1s78c1 (1s78 C:1-107)

1. Root: SCOP 1.71

2. Class b: All beta proteins [48724] (149 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (25 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (28 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (14 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Engineered (including hybrid species) [88533] (52 PDB entries)

8. Domain d1s78c1: 1s78 C:1-107 [98624]
   Other proteins in same PDB: d1s78a1, d1s78a2, d1s78a3, d1s78a4, d1s78b1, d1s78b2, d1s78b3, d1s78b4, d1s78c2, d1s78d1, d1s78d2, d1s78e2, d1s78f1, d1s78f2

Details for d1s78c1

PDB Entry: 1s78, 3.25 Å

PDB Description: insights into erbb signaling from the structure of the erbb2- pertuzumab complex

SCOP Domain Sequences for d1s78c1:

Sequence; same for both SEQRES and ATOM records:

>d1s78c1 b.1.1.1 (C:1-107) Immunoglobulin light chain kappa variable domain, VL-kappa {Engineered (including hybrid species)}
diqmtqspsslsasvgdrvtitckasqdvsigvawyqqkpgkapklliysasyrytgvps
rfsgsgsgtdftltisslqpedfatyycqqyyiypytfgqgtkveik

Timeline for d1s78c1:

• d1s78c1 first appeared in SCOP 1.67
  
• d1s78c1 appears in SCOP 1.69
  
• d1s78c1 appears in SCOP 1.73
  
• d1s78c1 appears in the current release, SCOPe 2.08