SCOPe 2.03: Domain d1s78a4: 1s78 A:489-564

Lineage for d1s78a4 (1s78 A:489-564)

1. Root: SCOPe 2.03

2. Class g: Small proteins [56992] (90 folds)

3. Fold g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
   disulfide-bound fold; contains beta-hairpin with two adjacent disulfides

4. Superfamily g.3.9: Growth factor receptor domain [57184] (2 families)

5. Family g.3.9.1: Growth factor receptor domain [57185] (9 proteins)

6. Protein Protooncoprotein Her2 extracellular domain [82889] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [82890] (2 PDB entries)

8. Domain d1s78a4: 1s78 A:489-564 [98619]
   Other proteins in same PDB: d1s78a1, d1s78a2, d1s78b1, d1s78b2, d1s78c1, d1s78c2, d1s78d1, d1s78d2, d1s78e1, d1s78e2, d1s78f1, d1s78f2
   complexed with nag

Details for d1s78a4

PDB Entry: 1s78, 3.25 Å

PDB Description: insights into erbb signaling from the structure of the erbb2- pertuzumab complex

PDB Compounds: (A:) Receptor protein-tyrosine kinase erbB-2

SCOPe Domain Sequences for d1s78a4:

Sequence; same for both SEQRES and ATOM records:

>d1s78a4 g.3.9.1 (A:489-564) Protooncoprotein Her2 extracellular domain {Human (Homo sapiens) [TaxId: 9606]}
chqlcarghcwgpgptqcvncsqflrgqecveecrvlqglpreyvnarhclpchpecqpq
ngsvtcfgpeadqcva

Timeline for d1s78a4:

• d1s78a4 first appeared in SCOP 1.67
  
• d1s78a4 appears in SCOPe 2.02
  
• d1s78a4 appears in SCOPe 2.04
  
• d1s78a4 appears in the current release, SCOPe 2.08