SCOPe 2.01: Domain d1s26a_: 1s26 A:

Lineage for d1s26a_ (1s26 A:)

1. Root: SCOPe 2.01

2. Class e: Multi-domain proteins (alpha and beta) [56572] (66 folds)

3. Fold e.41: Adenylylcyclase toxin (the edema factor) [81299] (1 superfamily)
   3 domains: (1&2) alpha+beta, with domain 2 being inserted in domain 1; (3) all-alpha

4. Superfamily e.41.1: Adenylylcyclase toxin (the edema factor) [81298] (1 family)
   Domain 1 has topological and active site similarity to the Nucleotidyltransferases (eg. 1kny N-domain); domain 3 binds calmodulin

5. Family e.41.1.1: Adenylylcyclase toxin (the edema factor) [69887] (1 protein)
   decorated with many insertions and the C-terminal domain

6. Protein Adenylylcyclase toxin (the edema factor) [69888] (1 species)

7. Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [69889] (7 PDB entries)
   Uniprot P40136

8. Domain d1s26a_: 1s26 A: [98367]
   Other proteins in same PDB: d1s26d_, d1s26e_, d1s26f_
   complexed with apc, ca, yb

Details for d1s26a_

PDB Entry: 1s26, 3 Å

PDB Description: structure of anthrax edema factor-calmodulin-alpha,beta- methyleneadenosine 5'-triphosphate complex reveals an alternative mode of atp binding to the catalytic site

PDB Compounds: (A:) calmodulin-sensitive adenylate cyclase

SCOPe Domain Sequences for d1s26a_:

Sequence, based on SEQRES records:

>d1s26a_ e.41.1.1 (A:) Adenylylcyclase toxin (the edema factor) {Anthrax bacillus (Bacillus anthracis) [TaxId: 1392]}
ridvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnvh
gkssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlrie
elkengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfnw
rnievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnslekqkgvtn
llikygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekdn
eifiinpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpitk
akintiptsaefiknlssirrssnvgvykdsgdkdefakkesvkkiagylsdyynsanhi
fsqekkrkisifrgiqayneienvlkskqiapeyknyfqylkeritnqvqlllthqksni
efkllykqlnftenetdnfevfqkiid

Sequence, based on observed residues (ATOM records):

>d1s26a_ e.41.1.1 (A:) Adenylylcyclase toxin (the edema factor) {Anthrax bacillus (Bacillus anthracis) [TaxId: 1392]}
ridvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnvh
gkssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlrie
elkengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfnw
rnievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnslekqkgvtn
llikygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekdn
eifiinpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpitk
akintiptsaefiknlssirrsssvkkiagylsdyynsanhifsqekkrkisifrgiqay
neienvlkskqiapeyknyfqylkeritnqvqlllthqkfkllykqlnftenetdnfevf
qkiid

Timeline for d1s26a_:

• d1s26a_ first appeared in SCOP 1.67
  
• d1s26a_ appears in SCOP 1.75
  
• d1s26a_ appears in SCOPe 2.02
  
• d1s26a_ appears in the current release, SCOPe 2.08