SCOPe 2.02: Domain d1q4la_: 1q4l A:

Lineage for d1q4la_ (1q4l A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Glycogen synthase kinase-3 beta (Gsk3b) [69823] (1 species)
   CMGC group; GSK3 subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [69824] (23 PDB entries)
   Uniprot P49841 35-383 ! Uniprot P49841 35-384

8. Domain d1q4la_: 1q4l A: [95803]
   complexed with 679

Details for d1q4la_

PDB Entry: 1q4l, 2.77 Å

PDB Description: GSK-3 Beta complexed with Inhibitor I-5

PDB Compounds: (A:) Glycogen synthase kinase-3 beta

SCOPe Domain Sequences for d1q4la_:

Sequence, based on SEQRES records:

>d1q4la_ d.144.1.7 (A:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
skvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfk
nrelqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlp
viyvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnv
syicsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlg
tptreqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltplea
cahsffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphariqa

Sequence, based on observed residues (ATOM records):

>d1q4la_ d.144.1.7 (A:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
skvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfk
nrelqimrkldhcnivrlryffyssgdevylnlvldyvpetvyrvarhysrakqtlpviy
vklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyi
csryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtpt
reqiremnfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsffdelr
dpnvklpngrdtpalfnfttqelssnpplatilipphariqa

Timeline for d1q4la_:

• d1q4la_ first appeared in SCOP 1.67
  
• d1q4la_ appears in SCOPe 2.01
  
• d1q4la_ appears in SCOPe 2.03
  
• d1q4la_ appears in the current release, SCOPe 2.08