SCOPe 2.04: Domain d1pyxa_: 1pyx A:

Lineage for d1pyxa_ (1pyx A:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Glycogen synthase kinase-3 beta (Gsk3b) [69823] (1 species)
   CMGC group; GSK3 subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [69824] (35 PDB entries)
   Uniprot P49841 35-383 ! Uniprot P49841 35-384

8. Domain d1pyxa_: 1pyx A: [95383]
   complexed with anp, mg

Details for d1pyxa_

PDB Entry: 1pyx, 2.4 Å

PDB Description: GSK-3 Beta complexed with AMP-PNP

PDB Compounds: (A:) Glycogen synthase kinase-3 beta

SCOPe Domain Sequences for d1pyxa_:

Sequence, based on SEQRES records:

>d1pyxa_ d.144.1.7 (A:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
skvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfk
nrelqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlp
viyvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnv
syicsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlg
tptreqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltplea
cahsffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphariqa

Sequence, based on observed residues (ATOM records):

>d1pyxa_ d.144.1.7 (A:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
skvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfk
nrelqimrkldhcnivrlryffyssevylnlvldyvpetvyrvarhysrakqtlpviyvk
lymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyics
ryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptre
qiremnpfkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsffdel
rdpnvklpngrdtpalfnfttqelssnpplatilipphariqa

Timeline for d1pyxa_:

• d1pyxa_ first appeared in SCOP 1.67
  
• d1pyxa_ appears in SCOPe 2.03
  
• d1pyxa_ appears in SCOPe 2.05
  
• d1pyxa_ appears in the current release, SCOPe 2.08