SCOPe 2.08: Domain d1pl8c2: 1pl8 C:146-316

Lineage for d1pl8c2 (1pl8 C:146-316)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain [51736] (19 proteins)
   N-terminal all-beta domain defines family

6. Protein Ketose reductase (sorbitol dehydrogenase) [51745] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [102130] (3 PDB entries)

8. Domain d1pl8c2: 1pl8 C:146-316 [94883]
   Other proteins in same PDB: d1pl8a1, d1pl8b1, d1pl8c1, d1pl8d1
   complexed with nad, zn

Details for d1pl8c2

PDB Entry: 1pl8, 1.9 Å

PDB Description: human SDH/NAD+ complex

PDB Compounds: (C:) human sorbitol dehydrogenase

SCOPe Domain Sequences for d1pl8c2:

Sequence; same for both SEQRES and ATOM records:

>d1pl8c2 c.2.1.1 (C:146-316) Ketose reductase (sorbitol dehydrogenase) {Human (Homo sapiens) [TaxId: 9606]}
vtfeegalieplsvgihacrrggvtlghkvlvcgagpigmvtllvakamgaaqvvvtdls
atrlskakeigadlvlqiskespqeiarkvegqlgckpevtiectgaeasiqagiyatrs
ggtlvlvglgsemttvpllhaairevdikgvfrycntwpvaismlasksvn

Timeline for d1pl8c2:

• d1pl8c2 first appeared in SCOP 1.67
  
• d1pl8c2 appears in SCOPe 2.07