SCOP 1.73: Domain d1mrva_: 1mrv A:

Lineage for d1mrva_ (1mrv A:)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Pkb kinase (Akt-2) [82791] (1 species)
   AGC group; RAC/Akt subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82792] (10 PDB entries)

8. Domain d1mrva_: 1mrv A: [91446]

Details for d1mrva_

PDB Entry: 1mrv, 2.8 Å

PDB Description: crystal structure of an inactive Akt2 kinase domain

PDB Compounds: (A:) RAC-beta serine/threonine kinase

SCOP Domain Sequences for d1mrva_:

Sequence, based on SEQRES records:

>d1mrva_ d.144.1.7 (A:) Pkb kinase (Akt-2) {Human (Homo sapiens) [TaxId: 9606]}
vtmndfdylkllgkgtfgkvilvrekatgryyamkilrkeviiakdevahtvtesrvlqn
trhpfltalkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeivsaleyl
hsrdvvyrdiklenlmldkdghikitdfglckegisdgatmktfcgtpeylapevlednd
ygravdwwglgvvmyemmcgrlpfynqdherlfelilmeeirfprtlspeaksllagllk
kdpkqrlgggpsdakevmehrfflsinwqdvvqkkllppfkpqvtsevdtryfd

Sequence, based on observed residues (ATOM records):

>d1mrva_ d.144.1.7 (A:) Pkb kinase (Akt-2) {Human (Homo sapiens) [TaxId: 9606]}
vtmndfdylkllgkgtfgkvilvrekatgryyamkilrkevivlqntrhpfltalkyafq
thdrlcfvmeyanggelffhlsrervfteerarfygaeivsaleylhsrdvvyrdiklen
lmldkdghikitdfpeylapevledndygravdwwglgvvmyemmcgrlpfynqdherlf
elilmeeirfprtlspeaksllagllkkdpkqrlgggpsdakevmehrfflsinwqdvvq
kkllppfkpqvtsevdtryfd

Timeline for d1mrva_:

• d1mrva_ first appeared in SCOP 1.67
  
• d1mrva_ appears in SCOP 1.71
  
• d1mrva_ appears in SCOP 1.75
  
• d1mrva_ appears in the current release, SCOPe 2.08