SCOP 1.73: Domain d1md7a1: 1md7 A:434-685

Lineage for d1md7a1 (1md7 A:434-685)

1. Root: SCOP 1.73

2. Class b: All beta proteins [48724] (165 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (47 proteins)

6. Protein Complement C1R protease, catalytic domain [74976] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [74977] (3 PDB entries)

8. Domain d1md7a1: 1md7 A:434-685 [91243]
   Other proteins in same PDB: d1md7a2
   complexed with nag; mutant

Details for d1md7a1

PDB Entry: 1md7, 3.2 Å

PDB Description: monomeric structure of the zymogen of complement protease c1r

PDB Compounds: (A:) c1r complement serine protease

SCOP Domain Sequences for d1md7a1:

Sequence, based on SEQRES records:

>d1md7a1 b.47.1.2 (A:434-685) Complement C1R protease, catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
cgkpvnpveqrqriiggqkakmgnfpwqvftnihgrgggallgdrwiltaahtlypkehe
aqsnasldvflghtnveelmklgnhpirrvsvhpdyrqdesynfegdiallelensvtlg
pnllpiclpdndtfydlglmgyvsgfgvmeekiahdlrfvrlpvanpqacenwlrgknrm
dvfsqnmfcaghpslkqdacqgdaggvfavrdpntdrwvatgivswgigcsrgygfytkv
lnyvdwikkeme

Sequence, based on observed residues (ATOM records):

>d1md7a1 b.47.1.2 (A:434-685) Complement C1R protease, catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
cgkpvnpveiiggqkakmgnfpwqvftnihgrgggallgdrwiltaahtlypkeheaqsn
asldvflghtnveelmklgnhpirrvsvhpdyrqdesynfegdiallelensvtlgpnll
piclpdndtfydlglmgyvsgfgahdlrfvrlpvanpqacenwldvfsqnmfcaghpslk
qdacqgdaggvfavrdpntdrwvatgivswgigcsrgygfytkvlnyvdwikkeme

Timeline for d1md7a1:

• d1md7a1 first appeared in SCOP 1.67
  
• d1md7a1 appears in SCOP 1.71
  
• d1md7a1 appears in SCOP 1.75
  
• d1md7a1 appears in the current release, SCOPe 2.08