SCOP 1.71: Domain d1j3vd2: 1j3v D:2-157

Lineage for d1j3vd2 (1j3v D:2-157)

1. Root: SCOP 1.71

2. Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (15 proteins)
   the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
   C-terminal domains also show some similarity

6. Protein Hydroxyisobutyrate dehydrogenase [102171] (2 species)

7. Species Thermus thermophilus [TaxId:274] [102172] (1 PDB entry)

8. Domain d1j3vd2: 1j3v D:2-157 [90832]
   Other proteins in same PDB: d1j3va1, d1j3vb1, d1j3vc1, d1j3vd1
   structural genomics
   complexed with ndp

Details for d1j3vd2

PDB Entry: 1j3v, 1.8 Å

PDB Description: Structure of Hydroxyisobutyrate Dehydrogenase from Thermus Thermophilus HB8

SCOP Domain Sequences for d1j3vd2:

Sequence; same for both SEQRES and ATOM records:

>d1j3vd2 c.2.1.6 (D:2-157) Hydroxyisobutyrate dehydrogenase {Thermus thermophilus}
ekvafiglgamgypmaghlarrfptlvwnrtfekalrhqeefgseavplervaearvift
clpttrevyevaealypylregtywvdatsgepeasrrlaerlrekgvtyldapvsggts
gaeagtltvmlggpeeavervrpflayakkvvhvgp

Timeline for d1j3vd2:

• d1j3vd2 first appeared in SCOP 1.67
  
• d1j3vd2 appears in SCOP 1.69
  
• d1j3vd2 does not appear in SCOP 1.73