SCOPe 2.05: Species: Human (Homo sapiens) [TaxId: 9606]

Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

Root: SCOPe 2.05
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest

Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (3 families)

transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds

Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (2 proteins)
the common fold is elaborated with additional (sub)domains

Protein Amyloid beta precursor protein-binding protein 1, APPBP1 [89766] (1 species)
a subunit of the heterodimeric E1 enzyme for NEDD8; contains a large insertion (residues 170-487) that can be divided into 3 units similar to the UBA3 insertion

Species Human (Homo sapiens) [TaxId:9606] [89767] (9 PDB entries)
Uniprot Q13564

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

Domain(s) for 1r4m:
1. Domain d1r4ma_: 1r4m A: [96999]
  Other proteins in same PDB: d1r4mb_, d1r4md_, d1r4mf_, d1r4mh_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
  complexed with zn
2. Domain d1r4mc_: 1r4m C: [97001]
  Other proteins in same PDB: d1r4mb_, d1r4md_, d1r4mf_, d1r4mh_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
  complexed with zn
3. Domain d1r4me_: 1r4m E: [97003]
  Other proteins in same PDB: d1r4mb_, d1r4md_, d1r4mf_, d1r4mh_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
  complexed with zn
4. Domain d1r4mg_: 1r4m G: [97005]
  Other proteins in same PDB: d1r4mb_, d1r4md_, d1r4mf_, d1r4mh_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
  complexed with zn
Domain(s) for 1r4n:
1. Domain d1r4na_: 1r4n A: [97011]
  Other proteins in same PDB: d1r4nb_, d1r4nd_, d1r4nf_, d1r4nh_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
  complexed with atp, zn
2. Domain d1r4nc_: 1r4n C: [97013]
  Other proteins in same PDB: d1r4nb_, d1r4nd_, d1r4nf_, d1r4nh_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
  complexed with atp, zn
3. Domain d1r4ne_: 1r4n E: [97015]
  Other proteins in same PDB: d1r4nb_, d1r4nd_, d1r4nf_, d1r4nh_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
  complexed with atp, zn
4. Domain d1r4ng_: 1r4n G: [97017]
  Other proteins in same PDB: d1r4nb_, d1r4nd_, d1r4nf_, d1r4nh_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
  complexed with atp, zn
Domain(s) for 1tt5:
1. Domain d1tt5a_: 1tt5 A: [107291]
  Other proteins in same PDB: d1tt5b_, d1tt5d_
  complexed with zn
2. Domain d1tt5c_: 1tt5 C: [107293]
  Other proteins in same PDB: d1tt5b_, d1tt5d_
  complexed with zn
Domain(s) for 1yov:
1. Domain d1yova_: 1yov A: [123785]
  Other proteins in same PDB: d1yovb_, d1yovd_
  automated match to d1tt5a_
  complexed with zn
2. Domain d1yovc_: 1yov C: [123787]
  Other proteins in same PDB: d1yovb_, d1yovd_
  automated match to d1tt5a_
  complexed with zn
Domain(s) for 2nvu:
- Domain d2nvua_: 2nvu A: [138660]
  Other proteins in same PDB: d2nvub1, d2nvub2, d2nvuc1, d2nvui_, d2nvuj_
  automated match to d1tt5a_
  complexed with atp, mg, zn
Domain(s) for 3dbh:
1. Domain d3dbha_: 3dbh A: [157468]
  Other proteins in same PDB: d3dbhb_, d3dbhd_, d3dbhf_, d3dbhh_, d3dbhi_, d3dbhj_, d3dbhk_, d3dbhl_
  automated match to d1tt5a_
  complexed with zn
2. Domain d3dbhc_: 3dbh C: [157469]
  Other proteins in same PDB: d3dbhb_, d3dbhd_, d3dbhf_, d3dbhh_, d3dbhi_, d3dbhj_, d3dbhk_, d3dbhl_
  automated match to d1tt5a_
  complexed with zn
3. Domain d3dbhe_: 3dbh E: [157470]
  Other proteins in same PDB: d3dbhb_, d3dbhd_, d3dbhf_, d3dbhh_, d3dbhi_, d3dbhj_, d3dbhk_, d3dbhl_
  automated match to d1tt5a_
  complexed with zn
4. Domain d3dbhg_: 3dbh G: [157471]
  Other proteins in same PDB: d3dbhb_, d3dbhd_, d3dbhf_, d3dbhh_, d3dbhi_, d3dbhj_, d3dbhk_, d3dbhl_
  automated match to d1tt5a_
  complexed with zn
Domain(s) for 3dbl:
1. Domain d3dbla_: 3dbl A: [157473]
  Other proteins in same PDB: d3dblb_, d3dbld_, d3dblf_, d3dblh_, d3dbli_, d3dblj_, d3dblk_, d3dbll_
  automated match to d1tt5a_
  complexed with zn
2. Domain d3dblc_: 3dbl C: [157475]
  Other proteins in same PDB: d3dblb_, d3dbld_, d3dblf_, d3dblh_, d3dbli_, d3dblj_, d3dblk_, d3dbll_
  automated match to d1tt5a_
  complexed with zn
3. Domain d3dble_: 3dbl E: [157477]
  Other proteins in same PDB: d3dblb_, d3dbld_, d3dblf_, d3dblh_, d3dbli_, d3dblj_, d3dblk_, d3dbll_
  automated match to d1tt5a_
  complexed with zn
4. Domain d3dblg_: 3dbl G: [157479]
  Other proteins in same PDB: d3dblb_, d3dbld_, d3dblf_, d3dblh_, d3dbli_, d3dblj_, d3dblk_, d3dbll_
  automated match to d1tt5a_
  complexed with zn
Domain(s) for 3dbr:
1. Domain d3dbra_: 3dbr A: [157482]
  Other proteins in same PDB: d3dbrb_, d3dbrd_, d3dbrf_, d3dbrh_, d3dbri_, d3dbrj_, d3dbrk_, d3dbrl_
  automated match to d1tt5a_
  complexed with zn
2. Domain d3dbrc_: 3dbr C: [157483]
  Other proteins in same PDB: d3dbrb_, d3dbrd_, d3dbrf_, d3dbrh_, d3dbri_, d3dbrj_, d3dbrk_, d3dbrl_
  automated match to d1tt5a_
  complexed with zn
3. Domain d3dbre_: 3dbr E: [157484]
  Other proteins in same PDB: d3dbrb_, d3dbrd_, d3dbrf_, d3dbrh_, d3dbri_, d3dbrj_, d3dbrk_, d3dbrl_
  automated match to d1tt5a_
  complexed with zn
4. Domain d3dbrg_: 3dbr G: [157485]
  Other proteins in same PDB: d3dbrb_, d3dbrd_, d3dbrf_, d3dbrh_, d3dbri_, d3dbrj_, d3dbrk_, d3dbrl_
  automated match to d1tt5a_
  complexed with zn
Domain(s) for 3gzn:
1. Domain d3gzna_: 3gzn A: [246396]
  Other proteins in same PDB: d3gznb_, d3gznd_, d3gzni_, d3gznj_
  automated match to d1tt5a_
  complexed with b39, zn
2. Domain d3gznc_: 3gzn C: [246398]
  Other proteins in same PDB: d3gznb_, d3gznd_, d3gzni_, d3gznj_
  automated match to d1tt5a_
  complexed with b39, zn

More info for Species Human (Homo sapiens) [TaxId:9606] from c.111.1.2 Amyloid beta precursor protein-binding protein 1, APPBP1

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.111.1.2 Amyloid beta precursor protein-binding protein 1, APPBP1:

Species Human (Homo sapiens) [TaxId:9606] from c.111.1.2 Amyloid beta precursor protein-binding protein 1, APPBP1 first appeared in SCOP 1.65
Species Human (Homo sapiens) [TaxId:9606] from c.111.1.2 Amyloid beta precursor protein-binding protein 1, APPBP1 appears in SCOPe 2.04
Species Human (Homo sapiens) [TaxId:9606] from c.111.1.2 Amyloid beta precursor protein-binding protein 1, APPBP1 appears in SCOPe 2.06
Species Human (Homo sapiens) [TaxId:9606] from c.111.1.2 Amyloid beta precursor protein-binding protein 1, APPBP1 appears in the current release, SCOPe 2.08