SCOP 1.71: Protein: Amyloid beta precursor protein-binding protein 1, APPBP1

Lineage for Protein: Amyloid beta precursor protein-binding protein 1, APPBP1

Root: SCOP 1.71
Class c: Alpha and beta proteins (a/b) [51349] (134 folds)
Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest

Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (2 families)

transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds

Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (2 proteins)
the common fold is elaborated with additional (sub)domains

Protein Amyloid beta precursor protein-binding protein 1, APPBP1 [89766] (1 species)
a subunit of the heterodimeric E1 enzyme for NEDD8; contains a large insertion (residues 170-487) that can be divided into 3 units similar to the UBA3 insertion

Species:

Human (Homo sapiens) [TaxId:9606] [89767] (4 PDB entries)
1. Domains for 1ngv:
  1. Domain d1ngva_: 1ngv A: [85698]
    Other proteins in same PDB: d1ngvb_, d1ngvd_
  2. Domain d1ngvc_: 1ngv C: [85700]
    Other proteins in same PDB: d1ngvb_, d1ngvd_
    complexed with zn
2. Domains for 1r4m:
  1. Domain d1r4ma_: 1r4m A: [96999]
    Other proteins in same PDB: d1r4mb_, d1r4md_, d1r4mf_, d1r4mh_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
  2. Domain d1r4mc_: 1r4m C: [97001]
    Other proteins in same PDB: d1r4mb_, d1r4md_, d1r4mf_, d1r4mh_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
  3. Domain d1r4me_: 1r4m E: [97003]
    Other proteins in same PDB: d1r4mb_, d1r4md_, d1r4mf_, d1r4mh_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
  4. Domain d1r4mg_: 1r4m G: [97005]
    Other proteins in same PDB: d1r4mb_, d1r4md_, d1r4mf_, d1r4mh_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
    complexed with zn; mutant
3. Domains for 1r4n:
  1. Domain d1r4na_: 1r4n A: [97011]
    Other proteins in same PDB: d1r4nb_, d1r4nd_, d1r4nf_, d1r4nh_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
  2. Domain d1r4nc_: 1r4n C: [97013]
    Other proteins in same PDB: d1r4nb_, d1r4nd_, d1r4nf_, d1r4nh_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
  3. Domain d1r4ne_: 1r4n E: [97015]
    Other proteins in same PDB: d1r4nb_, d1r4nd_, d1r4nf_, d1r4nh_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
  4. Domain d1r4ng_: 1r4n G: [97017]
    Other proteins in same PDB: d1r4nb_, d1r4nd_, d1r4nf_, d1r4nh_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
    complexed with atp, zn; mutant
4. Domains for 1tt5:
  1. Domain d1tt5a_: 1tt5 A: [107291]
    Other proteins in same PDB: d1tt5b_, d1tt5d_
  2. Domain d1tt5c_: 1tt5 C: [107293]
    Other proteins in same PDB: d1tt5b_, d1tt5d_
    complexed with zn

More info for Protein Amyloid beta precursor protein-binding protein 1, APPBP1 from c.111.1.2: Ubiquitin activating enzymes (UBA)

Timeline for Protein Amyloid beta precursor protein-binding protein 1, APPBP1 from c.111.1.2: Ubiquitin activating enzymes (UBA):

Protein Amyloid beta precursor protein-binding protein 1, APPBP1 from c.111.1.2: Ubiquitin activating enzymes (UBA) first appeared in SCOP 1.65
Protein Amyloid beta precursor protein-binding protein 1, APPBP1 from c.111.1.2: Ubiquitin activating enzymes (UBA) appears in SCOP 1.69
Protein Amyloid beta precursor protein-binding protein 1, APPBP1 from c.111.1.2: Ubiquitin activating enzymes (UBA) appears in SCOP 1.73
Protein Amyloid beta precursor protein-binding protein 1, APPBP1 from c.111.1.2: Ubiquitin activating enzymes (UBA) appears in the current release, SCOPe 2.08