Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 848423Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
  4. 848424Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (2 families) (S)
    transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
    the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds
  5. 848431Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (2 proteins)
    the common fold is elaborated with additional (sub)domains
  6. 848459Protein UBA3 [89764] (1 species)
    a subunit of the heterodimeric E1 enzyme for NEDD8; contains an all-alpha insert subdomain of the FF-like fold (residues 210-288) and an extra C-terminal alpha+beta subdomain (partly disordered)
  7. 848460Species Human (Homo sapiens) [TaxId:9606] [89765] (7 PDB entries)
    Uniprot Q8TBC4 33-458

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1r4m:
    1. 848467Domain d1r4mb_: 1r4m B: [97000]
      Other proteins in same PDB: d1r4ma_, d1r4mc_, d1r4me_, d1r4mg_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
    2. 848468Domain d1r4md_: 1r4m D: [97002]
      Other proteins in same PDB: d1r4ma_, d1r4mc_, d1r4me_, d1r4mg_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
    3. 848469Domain d1r4mf_: 1r4m F: [97004]
      Other proteins in same PDB: d1r4ma_, d1r4mc_, d1r4me_, d1r4mg_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
    4. 848470Domain d1r4mh_: 1r4m H: [97006]
      Other proteins in same PDB: d1r4ma_, d1r4mc_, d1r4me_, d1r4mg_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
      complexed with zn; mutant
  2. Domain(s) for 1r4n:
    1. 848475Domain d1r4nb_: 1r4n B: [97012]
      Other proteins in same PDB: d1r4na_, d1r4nc_, d1r4ne_, d1r4ng_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
    2. 848476Domain d1r4nd_: 1r4n D: [97014]
      Other proteins in same PDB: d1r4na_, d1r4nc_, d1r4ne_, d1r4ng_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
    3. 848477Domain d1r4nf_: 1r4n F: [97016]
      Other proteins in same PDB: d1r4na_, d1r4nc_, d1r4ne_, d1r4ng_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
    4. 848478Domain d1r4nh_: 1r4n H: [97018]
      Other proteins in same PDB: d1r4na_, d1r4nc_, d1r4ne_, d1r4ng_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
      complexed with atp, zn; mutant
  3. Domain(s) for 1tt5:
    1. 848464Domain d1tt5b_: 1tt5 B: [107292]
      Other proteins in same PDB: d1tt5a_, d1tt5c_
    2. 848465Domain d1tt5d_: 1tt5 D: [107294]
      Other proteins in same PDB: d1tt5a_, d1tt5c_
      complexed with zn
  4. Domain(s) for 1y8x:
  5. Domain(s) for 1yov:
    1. 848461Domain d1yovb1: 1yov B:12-437 [123786]
      Other proteins in same PDB: d1yova1, d1yovc1
      automatically matched to d1ngvb_
      complexed with zn
    2. 848462Domain d1yovd1: 1yov D:19-436 [123788]
      Other proteins in same PDB: d1yova1, d1yovc1
      automatically matched to d1ngvb_
      complexed with zn
  6. Domain(s) for 2nvu:
  7. Domain(s) for 3dbl:
    1. 848471Domain d3dblb1: 3dbl B:12-441 [157474]
      Other proteins in same PDB: d3dbla1, d3dblc1, d3dble1, d3dblg1, d3dbli1
      automatically matched to d1r4mb_
      complexed with zn; mutant
    2. 848472Domain d3dbld1: 3dbl D:12-441 [157476]
      Other proteins in same PDB: d3dbla1, d3dblc1, d3dble1, d3dblg1, d3dbli1
      automatically matched to d1r4mb_
      complexed with zn; mutant
    3. 848473Domain d3dblf1: 3dbl F:12-441 [157478]
      Other proteins in same PDB: d3dbla1, d3dblc1, d3dble1, d3dblg1, d3dbli1
      automatically matched to d1r4mb_
      complexed with zn; mutant
    4. 848474Domain d3dblh1: 3dbl H:12-441 [157480]
      Other proteins in same PDB: d3dbla1, d3dblc1, d3dble1, d3dblg1, d3dbli1
      automatically matched to d1r4mb_
      complexed with zn; mutant

More info for Species Human (Homo sapiens) [TaxId:9606] from c.111.1.2 UBA3

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.111.1.2 UBA3: