Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2864564Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 2864565Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 2864755Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (5 proteins)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
    automatically mapped to Pfam PF02779
  6. 2864793Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module [69472] (2 species)
  7. 2864794Species Human (Homo sapiens) [TaxId:9606] [89653] (4 PDB entries)

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1ni4:
    1. 2864797Domain d1ni4b1: 1ni4 B:1-191 [85729]
      Other proteins in same PDB: d1ni4a1, d1ni4a2, d1ni4b2, d1ni4b3, d1ni4c1, d1ni4c2, d1ni4d2, d1ni4d3
      complexed with k, mg, tpp
    2. 2864798Domain d1ni4d1: 1ni4 D:1-191 [85732]
      Other proteins in same PDB: d1ni4a1, d1ni4a2, d1ni4b2, d1ni4b3, d1ni4c1, d1ni4c2, d1ni4d2, d1ni4d3
      complexed with k, mg, tpp
  2. Domain(s) for 2ozl:
    1. 2864795Domain d2ozlb1: 2ozl B:2-191 [139447]
      Other proteins in same PDB: d2ozla1, d2ozla2, d2ozlb2, d2ozlb3, d2ozlc2, d2ozlc3, d2ozld2, d2ozld3
      automated match to d1ni4b1
      complexed with k, mg, tpp
    2. 2864796Domain d2ozld1: 2ozl D:2-191 [139449]
      Other proteins in same PDB: d2ozla1, d2ozla2, d2ozlb2, d2ozlb3, d2ozlc2, d2ozlc3, d2ozld2, d2ozld3
      automated match to d1ni4b1
      complexed with k, mg, tpp
  3. Domain(s) for 3exf:
    1. 2864799Domain d3exfb1: 3exf B:1-191 [245929]
      Other proteins in same PDB: d3exfa1, d3exfa2, d3exfb2, d3exfc1, d3exfc2, d3exfd2, d3exfe1, d3exfe2, d3exff2, d3exfg1, d3exfg2, d3exfh2
      automated match to d2ozlb1
      complexed with k, mg, tpp
    2. 2864800Domain d3exfd1: 3exf D:1-191 [245932]
      Other proteins in same PDB: d3exfa1, d3exfa2, d3exfb2, d3exfc1, d3exfc2, d3exfd2, d3exfe1, d3exfe2, d3exff2, d3exfg1, d3exfg2, d3exfh2
      automated match to d2ozlb1
      complexed with k, mg, tpp
    3. 2864801Domain d3exff1: 3exf F:1-191 [245935]
      Other proteins in same PDB: d3exfa1, d3exfa2, d3exfb2, d3exfc1, d3exfc2, d3exfd2, d3exfe1, d3exfe2, d3exff2, d3exfg1, d3exfg2, d3exfh2
      automated match to d2ozlb1
      complexed with k, mg, tpp
    4. 2864802Domain d3exfh1: 3exf H:1-191 [245938]
      Other proteins in same PDB: d3exfa1, d3exfa2, d3exfb2, d3exfc1, d3exfc2, d3exfd2, d3exfe1, d3exfe2, d3exff2, d3exfg1, d3exfg2, d3exfh2
      automated match to d2ozlb1
      complexed with k, mg, tpp
  4. Domain(s) for 3exg:
    1. 2864803Domain d3exg21: 3exg 2:1-191 [245941]
      Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
      automated match to d2ozlb1
      complexed with k
    2. 2864804Domain d3exg41: 3exg 4:1-191 [245944]
      Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
      automated match to d2ozlb1
      complexed with k
    3. 2864805Domain d3exg61: 3exg 6:1-191 [245947]
      Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
      automated match to d2ozlb1
      complexed with k
    4. 2864806Domain d3exgb1: 3exg B:1-191 [245950]
      Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
      automated match to d2ozlb1
      complexed with k
    5. 2864807Domain d3exgd1: 3exg D:1-191 [245953]
      Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
      automated match to d2ozlb1
      complexed with k
    6. 2864808Domain d3exgf1: 3exg F:1-191 [245956]
      Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
      automated match to d2ozlb1
      complexed with k
    7. 2864809Domain d3exgh1: 3exg H:1-191 [245959]
      Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
      automated match to d2ozlb1
      complexed with k
    8. 2864810Domain d3exgj1: 3exg J:1-191 [245962]
      Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
      automated match to d2ozlb1
      complexed with k
    9. 2864811Domain d3exgl1: 3exg L:1-191 [245965]
      Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
      automated match to d2ozlb1
      complexed with k
    10. 2864812Domain d3exgn1: 3exg N:1-191 [245968]
      Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
      automated match to d2ozlb1
      complexed with k
    11. 2864813Domain d3exgp1: 3exg P:1-191 [245971]
      Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
      automated match to d2ozlb1
      complexed with k
    12. 2864814Domain d3exgr1: 3exg R:1-191 [245974]
      Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
      automated match to d2ozlb1
      complexed with k
    13. 2864815Domain d3exgt1: 3exg T:1-191 [245977]
      Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
      automated match to d2ozlb1
      complexed with k
    14. 2864816Domain d3exgv1: 3exg V:1-191 [245980]
      Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
      automated match to d2ozlb1
      complexed with k
    15. 2864817Domain d3exgx1: 3exg X:1-191 [245983]
      Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
      automated match to d2ozlb1
      complexed with k
    16. 2864818Domain d3exgz1: 3exg Z:1-191 [245986]
      Other proteins in same PDB: d3exg11, d3exg12, d3exg22, d3exg31, d3exg32, d3exg42, d3exg51, d3exg52, d3exg62, d3exga1, d3exga2, d3exgb2, d3exgc1, d3exgc2, d3exgd2, d3exge1, d3exge2, d3exgf2, d3exgg1, d3exgg2, d3exgh2, d3exgi1, d3exgi2, d3exgj2, d3exgk1, d3exgk2, d3exgl2, d3exgm1, d3exgm2, d3exgn2, d3exgo1, d3exgo2, d3exgp2, d3exgq1, d3exgq2, d3exgr2, d3exgs_, d3exgt2, d3exgu1, d3exgu2, d3exgv2, d3exgw1, d3exgw2, d3exgx2, d3exgy1, d3exgy2, d3exgz2
      automated match to d2ozlb1
      complexed with k

More info for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 E1-beta subunit of pyruvate dehydrogenase, Pyr module

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.36.1.7 E1-beta subunit of pyruvate dehydrogenase, Pyr module: