Lineage for Protein: E1-beta subunit of pyruvate dehydrogenase (PP module)
- Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds) 
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) 
there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 proteins)
parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
Protein E1-beta subunit of pyruvate dehydrogenase (PP module) [89651] (1 species)
Species:
Human (Homo sapiens) [TaxId:9606] [89652] (7 PDB entries) - Domains for 1ni4:
Domain d1ni4a1: 1ni4 A:1-361 [85728]
Other proteins in same PDB: d1ni4a2, d1ni4b1, d1ni4b2, d1ni4b3, d1ni4c2, d1ni4d1, d1ni4d2, d1ni4d3
complexed with k, mg, tpp
Domain d1ni4c1: 1ni4 C:1-361 [85731]
Other proteins in same PDB: d1ni4a2, d1ni4b1, d1ni4b2, d1ni4b3, d1ni4c2, d1ni4d1, d1ni4d2, d1ni4d3
complexed with k, mg, tpp
- Domains for 2ozl:
Domain d2ozla1: 2ozl A:1-361 [145744]
Other proteins in same PDB: d2ozla2, d2ozlb1, d2ozlb2, d2ozlb3, d2ozlc3, d2ozld1, d2ozld2, d2ozld3
complexed with k, mg, tpp
Domain d2ozlc2: 2ozl C:1-361 [145745]
Other proteins in same PDB: d2ozla2, d2ozlb1, d2ozlb2, d2ozlb3, d2ozlc3, d2ozld1, d2ozld2, d2ozld3
automated match to d1ni4a_
complexed with k, mg, tpp
- Domains for 3exe:
Domain d3exea1: 3exe A:1-361 [209698]
Other proteins in same PDB: d3exea2, d3exeb1, d3exeb2, d3exec2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeg2, d3exeh1, d3exeh2
automated match to d1ni4a_
complexed with gol, k, mn, tpp
Domain d3exec1: 3exe C:1-361 [209701]
Other proteins in same PDB: d3exea2, d3exeb1, d3exeb2, d3exec2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeg2, d3exeh1, d3exeh2
automated match to d1ni4a_
complexed with gol, k, mn, tpp
Domain d3exee_: 3exe E: [209704]
Other proteins in same PDB: d3exea2, d3exeb1, d3exeb2, d3exec2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeg2, d3exeh1, d3exeh2
automated match to d1ni4a_
complexed with gol, k, mn, tpp
Domain d3exeg1: 3exe G:1-361 [209707]
Other proteins in same PDB: d3exea2, d3exeb1, d3exeb2, d3exec2, d3exed1, d3exed2, d3exef1, d3exef2, d3exeg2, d3exeh1, d3exeh2
automated match to d1ni4a_
complexed with gol, k, mn, tpp
- Domains for 3exf:
Domain d3exfa1: 3exf A:1-361 [245928]
Other proteins in same PDB: d3exfa2, d3exfb1, d3exfb2, d3exfc2, d3exfd1, d3exfd2, d3exfe2, d3exff1, d3exff2, d3exfg2, d3exfh1, d3exfh2
automated match to d3exia_
complexed with k, mg, tpp
Domain d3exfc1: 3exf C:1-361 [245931]
Other proteins in same PDB: d3exfa2, d3exfb1, d3exfb2, d3exfc2, d3exfd1, d3exfd2, d3exfe2, d3exff1, d3exff2, d3exfg2, d3exfh1, d3exfh2
automated match to d3exia_
complexed with k, mg, tpp
Domain d3exfe1: 3exf E:1-361 [245934]
Other proteins in same PDB: d3exfa2, d3exfb1, d3exfb2, d3exfc2, d3exfd1, d3exfd2, d3exfe2, d3exff1, d3exff2, d3exfg2, d3exfh1, d3exfh2
automated match to d3exia_
complexed with k, mg, tpp
Domain d3exfg1: 3exf G:1-361 [245937]
Other proteins in same PDB: d3exfa2, d3exfb1, d3exfb2, d3exfc2, d3exfd1, d3exfd2, d3exfe2, d3exff1, d3exff2, d3exfg2, d3exfh1, d3exfh2
automated match to d3exia_
complexed with k, mg, tpp
- Domains for 3exg:
Domain d3exg11: 3exg 1:1-361 [245940]
Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
automated match to d3exia_
complexed with k
Domain d3exg31: 3exg 3:1-361 [245943]
Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
automated match to d3exia_
complexed with k
Domain d3exg51: 3exg 5:1-361 [245946]
Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
automated match to d3exia_
complexed with k
Domain d3exga1: 3exg A:1-361 [245949]
Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
automated match to d3exia_
complexed with k
Domain d3exgc1: 3exg C:1-361 [245952]
Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
automated match to d3exia_
complexed with k
Domain d3exge1: 3exg E:1-361 [245955]
Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
automated match to d3exia_
complexed with k
Domain d3exgg1: 3exg G:1-361 [245958]
Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
automated match to d3exia_
complexed with k
Domain d3exgi1: 3exg I:1-361 [245961]
Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
automated match to d3exia_
complexed with k
Domain d3exgk1: 3exg K:1-361 [245964]
Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
automated match to d3exia_
complexed with k
Domain d3exgm1: 3exg M:1-361 [245967]
Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
automated match to d3exia_
complexed with k
Domain d3exgo1: 3exg O:1-361 [245970]
Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
automated match to d3exia_
complexed with k
Domain d3exgq1: 3exg Q:1-361 [245973]
Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
automated match to d3exia_
complexed with k
Domain d3exgs_: 3exg S: [245976]
Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
automated match to d3exia_
complexed with k
Domain d3exgu1: 3exg U:1-361 [245979]
Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
automated match to d3exia_
complexed with k
Domain d3exgw1: 3exg W:1-361 [245982]
Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
automated match to d3exia_
complexed with k
Domain d3exgy1: 3exg Y:1-361 [245985]
Other proteins in same PDB: d3exg12, d3exg21, d3exg22, d3exg32, d3exg41, d3exg42, d3exg52, d3exg61, d3exg62, d3exga2, d3exgb1, d3exgb2, d3exgc2, d3exgd1, d3exgd2, d3exge2, d3exgf1, d3exgf2, d3exgg2, d3exgh1, d3exgh2, d3exgi2, d3exgj1, d3exgj2, d3exgk2, d3exgl1, d3exgl2, d3exgm2, d3exgn1, d3exgn2, d3exgo2, d3exgp1, d3exgp2, d3exgq2, d3exgr1, d3exgr2, d3exgt1, d3exgt2, d3exgu2, d3exgv1, d3exgv2, d3exgw2, d3exgx1, d3exgx2, d3exgy2, d3exgz1, d3exgz2
automated match to d3exia_
complexed with k
- Domains for 3exh:
Domain d3exha1: 3exh A:1-361 [209710]
Other proteins in same PDB: d3exha2, d3exhb1, d3exhb2, d3exhc2, d3exhd1, d3exhd2, d3exhe2, d3exhf1, d3exhf2, d3exhg2, d3exhh1, d3exhh2
automated match to d1ni4a_
complexed with gol, k, mn, tpp
Domain d3exhc1: 3exh C:1-361 [209713]
Other proteins in same PDB: d3exha2, d3exhb1, d3exhb2, d3exhc2, d3exhd1, d3exhd2, d3exhe2, d3exhf1, d3exhf2, d3exhg2, d3exhh1, d3exhh2
automated match to d1ni4a_
complexed with gol, k, mn, tpp
Domain d3exhe1: 3exh E:1-361 [209716]
Other proteins in same PDB: d3exha2, d3exhb1, d3exhb2, d3exhc2, d3exhd1, d3exhd2, d3exhe2, d3exhf1, d3exhf2, d3exhg2, d3exhh1, d3exhh2
automated match to d1ni4a_
complexed with gol, k, mn, tpp
Domain d3exhg1: 3exh G:1-361 [209719]
Other proteins in same PDB: d3exha2, d3exhb1, d3exhb2, d3exhc2, d3exhd1, d3exhd2, d3exhe2, d3exhf1, d3exhf2, d3exhg2, d3exhh1, d3exhh2
automated match to d1ni4a_
complexed with gol, k, mn, tpp
- Domain for 3exi:
Domain d3exia1: 3exi A:1-361 [209722]
Other proteins in same PDB: d3exia2, d3exib1, d3exib2
automated match to d1ni4a_
complexed with cl, k
- Domains for 1ni4:
More info for Protein E1-beta subunit of pyruvate dehydrogenase (PP module) from c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module
Timeline for Protein E1-beta subunit of pyruvate dehydrogenase (PP module) from c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module:
- Protein E1-beta subunit of pyruvate dehydrogenase (PP module) from c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module first appeared in SCOP 1.65, called Protein E1-beta subunit of pyruvate dehydrogenase (PP module) from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module
- Protein E1-beta subunit of pyruvate dehydrogenase (PP module) from c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module appears in SCOPe 2.07