SCOP 1.71: Species: Human (Homo sapiens)

Lineage for Species: Human (Homo sapiens)

Root: SCOP 1.71
Class d: Alpha and beta proteins (a+b) [53931] (286 folds)
Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
shares functional and structural similarities with the ATP-grasp fold and PIPK
Family d.144.1.7: Protein kinases, catalytic subunit [88854] (60 proteins)
members organized in the groups and subfamiles specified by the comments
Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
CMGC group; CDKs subfamily; serine/threonine kinase
Species Human (Homo sapiens) [TaxId:9606] [88856] (80 PDB entries)

PDB entries in Species: Human (Homo sapiens):

Domain(s) for 1aq1:
- Domain d1aq1__: 1aq1 - [41599]
  complexed with stu
Domain(s) for 1b38:
- Domain d1b38a_: 1b38 A: [41595]
  complexed with ace, atp, ium
Domain(s) for 1b39:
- Domain d1b39a_: 1b39 A: [41600]
  complexed with ace, atp, ium
Domain(s) for 1buh:
- Domain d1buha_: 1buh A: [41608]
  Other proteins in same PDB: d1buhb_
Domain(s) for 1ckp:
- Domain d1ckpa_: 1ckp A: [41597]
  complexed with edo, pvb
Domain(s) for 1di8:
- Domain d1di8a_: 1di8 A: [41601]
  complexed with dtq
Domain(s) for 1dm2:
- Domain d1dm2a_: 1dm2 A: [41598]
  complexed with egl, hmd
Domain(s) for 1e1v:
- Domain d1e1va_: 1e1v A: [59156]
  complexed with ace, cmg
Domain(s) for 1e1x:
- Domain d1e1xa_: 1e1x A: [59157]
  complexed with ace, nw1
Domain(s) for 1e9h:
1. Domain d1e9ha_: 1e9h A: [64812]
  Other proteins in same PDB: d1e9hb1, d1e9hb2, d1e9hd1, d1e9hd2
2. Domain d1e9hc_: 1e9h C: [64815]
  Other proteins in same PDB: d1e9hb1, d1e9hb2, d1e9hd1, d1e9hd2
  complexed with inr
Domain(s) for 1f5q:
1. Domain d1f5qa_: 1f5q A: [41611]
  Other proteins in same PDB: d1f5qb1, d1f5qb2, d1f5qd1, d1f5qd2
2. Domain d1f5qc_: 1f5q C: [41612]
  Other proteins in same PDB: d1f5qb1, d1f5qb2, d1f5qd1, d1f5qd2
  complexed with cl
Domain(s) for 1fin:
1. Domain d1fina_: 1fin A: [41606]
  Other proteins in same PDB: d1finb1, d1finb2, d1find1, d1find2
2. Domain d1finc_: 1fin C: [41607]
  Other proteins in same PDB: d1finb1, d1finb2, d1find1, d1find2
  complexed with atp
Domain(s) for 1fq1:
- Domain d1fq1b_: 1fq1 B: [59983]
  Other proteins in same PDB: d1fq1a_
  complexed with atp, mg; mutant
Domain(s) for 1fvt:
- Domain d1fvta_: 1fvt A: [41602]
  complexed with 106
Domain(s) for 1fvv:
1. Domain d1fvva_: 1fvv A: [41615]
  Other proteins in same PDB: d1fvvb1, d1fvvb2, d1fvvd1, d1fvvd2
2. Domain d1fvvc_: 1fvv C: [41616]
  Other proteins in same PDB: d1fvvb1, d1fvvb2, d1fvvd1, d1fvvd2
  complexed with 107
Domain(s) for 1g5s:
- Domain d1g5sa_: 1g5s A: [65167]
  complexed with i17
Domain(s) for 1gih:
- Domain d1giha_: 1gih A: [65217]
  complexed with 1pu
Domain(s) for 1gii:
- Domain d1giia_: 1gii A: [65218]
  complexed with 1pu; mutant
Domain(s) for 1gij:
- Domain d1gija_: 1gij A: [65219]
  complexed with 2pu; mutant
Domain(s) for 1gy3:
1. Domain d1gy3a_: 1gy3 A: [70728]
  Other proteins in same PDB: d1gy3b1, d1gy3b2, d1gy3d1, d1gy3d2
2. Domain d1gy3c_: 1gy3 C: [70731]
  Other proteins in same PDB: d1gy3b1, d1gy3b2, d1gy3d1, d1gy3d2
  complexed with atp, gol, mg, no3, tpo
Domain(s) for 1gz8:
- Domain d1gz8a_: 1gz8 A: [83405]
  complexed with csw, mbp
Domain(s) for 1h00:
- Domain d1h00a_: 1h00 A: [83409]
  complexed with ace, fap, fcp
Domain(s) for 1h01:
- Domain d1h01a_: 1h01 A: [83410]
  complexed with fal, fbl, gol, kcx
Domain(s) for 1h07:
- Domain d1h07a_: 1h07 A: [83418]
  complexed with ace, mfp, mfq
Domain(s) for 1h08:
- Domain d1h08a_: 1h08 A: [83419]
  complexed with ace, bwp, byp, gol
Domain(s) for 1h0v:
- Domain d1h0va_: 1h0v A: [83443]
  complexed with un4
Domain(s) for 1h0w:
- Domain d1h0wa_: 1h0w A: [83444]
  complexed with 207
Domain(s) for 1h1p:
1. Domain d1h1pa_: 1h1p A: [76477]
  Other proteins in same PDB: d1h1pb1, d1h1pb2, d1h1pd1, d1h1pd2
2. Domain d1h1pc_: 1h1p C: [76480]
  Other proteins in same PDB: d1h1pb1, d1h1pb2, d1h1pd1, d1h1pd2
  complexed with cmg, tpo
Domain(s) for 1h1q:
1. Domain d1h1qa_: 1h1q A: [76483]
  Other proteins in same PDB: d1h1qb1, d1h1qb2, d1h1qd1, d1h1qd2
2. Domain d1h1qc_: 1h1q C: [76486]
  Other proteins in same PDB: d1h1qb1, d1h1qb2, d1h1qd1, d1h1qd2
  complexed with 2a6, tpo
Domain(s) for 1h1r:
1. Domain d1h1ra_: 1h1r A: [76489]
  Other proteins in same PDB: d1h1rb1, d1h1rb2, d1h1rd1, d1h1rd2
2. Domain d1h1rc_: 1h1r C: [76492]
  Other proteins in same PDB: d1h1rb1, d1h1rb2, d1h1rd1, d1h1rd2
  complexed with 6cp, tpo
Domain(s) for 1h1s:
1. Domain d1h1sa_: 1h1s A: [76495]
  Other proteins in same PDB: d1h1sb1, d1h1sb2, d1h1sd1, d1h1sd2
2. Domain d1h1sc_: 1h1s C: [76498]
  Other proteins in same PDB: d1h1sb1, d1h1sb2, d1h1sd1, d1h1sd2
  complexed with 4sp, tpo
Domain(s) for 1h24:
1. Domain d1h24a_: 1h24 A: [76516]
  Other proteins in same PDB: d1h24b1, d1h24b2, d1h24d1, d1h24d2
2. Domain d1h24c_: 1h24 C: [76519]
  Other proteins in same PDB: d1h24b1, d1h24b2, d1h24d1, d1h24d2
  complex with cyclin and a 9 residue recruitment peptide from E2F
  complexed with tpo

Domain(s) for 1h25:

Domain d1h25a_: 1h25 A: [76522]
Other proteins in same PDB: d1h25b1, d1h25b2, d1h25d1, d1h25d2

Domain d1h25c_: 1h25 C: [76525]
Other proteins in same PDB: d1h25b1, d1h25b2, d1h25d1, d1h25d2
complex with cyclin and an 11-residue recruitment peptide from retinoblastoma-associated protein
complexed with tpo

Domain(s) for 1h26:
1. Domain d1h26a_: 1h26 A: [76528]
  Other proteins in same PDB: d1h26b1, d1h26b2, d1h26d1, d1h26d2
2. Domain d1h26c_: 1h26 C: [76531]
  Other proteins in same PDB: d1h26b1, d1h26b2, d1h26d1, d1h26d2
  complex with cyclin and an 11-residue recruitment peptide from p53
  complexed with tpo
Domain(s) for 1h27:
1. Domain d1h27a_: 1h27 A: [76534]
  Other proteins in same PDB: d1h27b1, d1h27b2, d1h27d1, d1h27d2
2. Domain d1h27c_: 1h27 C: [76537]
  Other proteins in same PDB: d1h27b1, d1h27b2, d1h27d1, d1h27d2
  complex with cyclin and an 11-residue recruitment peptide from p27
  complexed with tpo
Domain(s) for 1h28:
1. Domain d1h28a_: 1h28 A: [76540]
  Other proteins in same PDB: d1h28b1, d1h28b2, d1h28d1, d1h28d2
2. Domain d1h28c_: 1h28 C: [76543]
  Other proteins in same PDB: d1h28b1, d1h28b2, d1h28d1, d1h28d2
  complex with cyclin and an 11-residue recruitment peptide from p107
  complexed with tpo
Domain(s) for 1hck:
- Domain d1hck__: 1hck - [41594]
  complexed with atp, mg
Domain(s) for 1hcl:
- Domain d1hcl__: 1hcl - [41593]
Domain(s) for 1jst:
1. Domain d1jsta_: 1jst A: [41609]
  Other proteins in same PDB: d1jstb1, d1jstb2, d1jstd1, d1jstd2
2. Domain d1jstc_: 1jst C: [41610]
  Other proteins in same PDB: d1jstb1, d1jstb2, d1jstd1, d1jstd2
  complexed with atp, mn
Domain(s) for 1jsu:
- Domain d1jsua_: 1jsu A: [41603]
  Other proteins in same PDB: d1jsub1, d1jsub2, d1jsuc_
  complexed with so4; mutant
Domain(s) for 1jsv:
- Domain d1jsva_: 1jsv A: [63278]
  complexed with u55
Domain(s) for 1jvp:
- Domain d1jvpp_: 1jvp P: [67371]
  complexed with lig
Domain(s) for 1ke5:
- Domain d1ke5a_: 1ke5 A: [72364]
  complexed with ls1
Domain(s) for 1ke6:
- Domain d1ke6a_: 1ke6 A: [72365]
  complexed with ls2
Domain(s) for 1ke7:
- Domain d1ke7a_: 1ke7 A: [72366]
  complexed with ls3
Domain(s) for 1ke8:
- Domain d1ke8a_: 1ke8 A: [72367]
  complexed with ls4
Domain(s) for 1ke9:
- Domain d1ke9a_: 1ke9 A: [72368]
  complexed with ls5
Domain(s) for 1ogu:
1. Domain d1ogua_: 1ogu A: [92942]
  Other proteins in same PDB: d1ogub1, d1ogub2, d1ogud1, d1ogud2
2. Domain d1oguc_: 1ogu C: [92945]
  Other proteins in same PDB: d1ogub1, d1ogub2, d1ogud1, d1ogud2
  complex with cyclin
  complexed with sgm, st8
Domain(s) for 1oi9:
1. Domain d1oi9a_: 1oi9 A: [103946]
  Other proteins in same PDB: d1oi9b1, d1oi9b2, d1oi9d1, d1oi9d2
2. Domain d1oi9c_: 1oi9 C: [103949]
  Other proteins in same PDB: d1oi9b1, d1oi9b2, d1oi9d1, d1oi9d2
  complexed with mg, n20, sgm
Domain(s) for 1oiq:
- Domain d1oiqa_: 1oiq A: [93073]
  complexed with hdu
Domain(s) for 1oir:
- Domain d1oira_: 1oir A: [93074]
  complexed with hdy
Domain(s) for 1oit:
- Domain d1oita_: 1oit A: [93075]
  complexed with hdt
Domain(s) for 1oiu:
1. Domain d1oiua_: 1oiu A: [103958]
  Other proteins in same PDB: d1oiub1, d1oiub2, d1oiud1, d1oiud2
2. Domain d1oiuc_: 1oiu C: [103961]
  Other proteins in same PDB: d1oiub1, d1oiub2, d1oiud1, d1oiud2
  complexed with mg, n76, sgm
Domain(s) for 1oiy:
1. Domain d1oiya_: 1oiy A: [103964]
  Other proteins in same PDB: d1oiyb1, d1oiyb2, d1oiyd1, d1oiyd2
2. Domain d1oiyc_: 1oiy C: [103967]
  Other proteins in same PDB: d1oiyb1, d1oiyb2, d1oiyd1, d1oiyd2
  complexed with mg, n41, sgm
Domain(s) for 1oku:
1. Domain d1okua_: 1oku A: [93276]
  Other proteins in same PDB: d1okub1, d1okub2, d1okud1, d1okud2
2. Domain d1okuc_: 1oku C: [93279]
  Other proteins in same PDB: d1okub1, d1okub2, d1okud1, d1okud2
  complex with cyclin
  complexed with aba, nh2, pff
Domain(s) for 1okv:
1. Domain d1okva_: 1okv A: [93282]
  Other proteins in same PDB: d1okvb1, d1okvb2, d1okvd1, d1okvd2
2. Domain d1okvc_: 1okv C: [93285]
  Other proteins in same PDB: d1okvb1, d1okvb2, d1okvd1, d1okvd2
  complex with cyclin
  complexed with nh2
Domain(s) for 1okw:
1. Domain d1okwa_: 1okw A: [93288]
  Other proteins in same PDB: d1okwb1, d1okwb2, d1okwd1, d1okwd2
2. Domain d1okwc_: 1okw C: [93291]
  Other proteins in same PDB: d1okwb1, d1okwb2, d1okwd1, d1okwd2
  complex with cyclin
  complexed with ace, fcl, nh2
Domain(s) for 1ol1:
1. Domain d1ol1a_: 1ol1 A: [93298]
  Other proteins in same PDB: d1ol1b1, d1ol1b2, d1ol1d1, d1ol1d2
2. Domain d1ol1c_: 1ol1 C: [93301]
  Other proteins in same PDB: d1ol1b1, d1ol1b2, d1ol1d1, d1ol1d2
  complex with cyclin
  complexed with cir, nh2, pff
Domain(s) for 1ol2:
1. Domain d1ol2a_: 1ol2 A: [93304]
  Other proteins in same PDB: d1ol2b1, d1ol2b2, d1ol2d1, d1ol2d2
2. Domain d1ol2c_: 1ol2 C: [93307]
  Other proteins in same PDB: d1ol2b1, d1ol2b2, d1ol2d1, d1ol2d2
  complex with cyclin
  complexed with nh2, pff
Domain(s) for 1p2a:
- Domain d1p2aa_: 1p2a A: [87719]
  complexed with 5bn
Domain(s) for 1p5e:
1. Domain d1p5ea_: 1p5e A: [87796]
  Other proteins in same PDB: d1p5eb1, d1p5eb2, d1p5ed1, d1p5ed2
2. Domain d1p5ec_: 1p5e C: [87799]
  Other proteins in same PDB: d1p5eb1, d1p5eb2, d1p5ed1, d1p5ed2
  complexed with tbs, tpo
Domain(s) for 1pf8:
- Domain d1pf8a_: 1pf8 A: [94605]
  complexed with su9
Domain(s) for 1pkd:
1. Domain d1pkda_: 1pkd A: [88141]
  Other proteins in same PDB: d1pkdb1, d1pkdb2, d1pkdd1, d1pkdd2
2. Domain d1pkdc_: 1pkd C: [88144]
  Other proteins in same PDB: d1pkdb1, d1pkdb2, d1pkdd1, d1pkdd2
  complexed with tpo, ucn
Domain(s) for 1pw2:
- Domain d1pw2a_: 1pw2 A: [95197]
Domain(s) for 1pxi:
- Domain d1pxia_: 1pxi A: [95289]
  complexed with ck1
Domain(s) for 1pxj:
- Domain d1pxja_: 1pxj A: [95290]
  complexed with ck2
Domain(s) for 1pxk:
- Domain d1pxka_: 1pxk A: [95291]
  complexed with ck3
Domain(s) for 1pxl:
- Domain d1pxla_: 1pxl A: [95292]
  complexed with ck4
Domain(s) for 1pxm:
- Domain d1pxma_: 1pxm A: [95293]
  complexed with ck5
Domain(s) for 1pxn:
- Domain d1pxna_: 1pxn A: [95294]
  complexed with ck6
Domain(s) for 1pxo:
- Domain d1pxoa_: 1pxo A: [95295]
  complexed with ck7
Domain(s) for 1pxp:
- Domain d1pxpa_: 1pxp A: [95296]
  complexed with ck8
Domain(s) for 1pye:
- Domain d1pyea_: 1pye A: [104390]
  complexed with pm1
Domain(s) for 1qmz:
1. Domain d1qmza_: 1qmz A: [41604]
  Other proteins in same PDB: d1qmzb1, d1qmzb2, d1qmzd1, d1qmzd2
2. Domain d1qmzc_: 1qmz C: [41605]
  Other proteins in same PDB: d1qmzb1, d1qmzb2, d1qmzd1, d1qmzd2
Domain(s) for 1r78:
- Domain d1r78a_: 1r78 A: [97190]
  complexed with fmd
Domain(s) for 1urc:
1. Domain d1urca_: 1urc A: [113404]
  Other proteins in same PDB: d1urcb1, d1urcb2, d1urcd1, d1urcd2
2. Domain d1urcc_: 1urc C: [113407]
  Other proteins in same PDB: d1urcb1, d1urcb2, d1urcd1, d1urcd2
  complexed with ace
Domain(s) for 1urw:
- Domain d1urwa_: 1urw A: [99836]
  complexed with ace, i1p
Domain(s) for 1v1k:
- Domain d1v1ka_: 1v1k A: [100255]
  complexed with 3fp, ace
Domain(s) for 1vyw:
1. Domain d1vywa_: 1vyw A: [108922]
  Other proteins in same PDB: d1vywb1, d1vywb2, d1vywd1, d1vywd2
2. Domain d1vywc_: 1vyw C: [108925]
  Other proteins in same PDB: d1vywb1, d1vywb2, d1vywd1, d1vywd2
  complexed with 292, so4
Domain(s) for 1vyz:
- Domain d1vyza_: 1vyz A: [108928]
  complexed with n5b

More info for Species Human (Homo sapiens) [TaxId:9606] from d.144.1.7 Cyclin-dependent PK, CDK2

Timeline for Species Human (Homo sapiens) [TaxId:9606] from d.144.1.7 Cyclin-dependent PK, CDK2:

Species Human (Homo sapiens) [TaxId:9606] from d.144.1.7 Cyclin-dependent PK, CDK2 first appeared in SCOP 1.65
Species Human (Homo sapiens) [TaxId:9606] from d.144.1.7 Cyclin-dependent PK, CDK2 appears in SCOP 1.69
Species Human (Homo sapiens) [TaxId:9606] from d.144.1.7 Cyclin-dependent PK, CDK2 appears in SCOP 1.73
Species Human (Homo sapiens) [TaxId:9606] from d.144.1.7 Cyclin-dependent PK, CDK2 appears in the current release, SCOPe 2.08