SCOP 1.75: Family c.66.1.25: mRNA cap methylase

Lineage for Family c.66.1.25: mRNA cap methylase

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (57 families)

5. Family c.66.1.25: mRNA cap methylase [88785] (2 proteins)

Proteins:

1. An RNA cap (nucleoside-2'-O-)-methyltransferase domain of RNA polymerase NS5 [89741] (2 species)
   structurally and functionally similar to VP39

   1. Species Dengue virus 2 [TaxId:11060] [159679] (5 PDB entries)

   2. Species Flavivirus (Dengue virus type 2) [TaxId:12637] [89742] (3 PDB entries)
      Uniprot P12823 2495-2756

2. Polymerase regulatory subunit VP39 [53361] (1 species)

   • Species Vaccinia virus [TaxId:10245] [53362] (19 PDB entries)

More info for Family c.66.1.25: mRNA cap methylase

Timeline for Family c.66.1.25: mRNA cap methylase:

• Family c.66.1.25: mRNA cap methylase first appeared in SCOP 1.65
  
• Family c.66.1.25: mRNA cap methylase appears in SCOP 1.73
  
• Family c.66.1.25: mRNA cap methylase appears in SCOPe 2.01
  
• Family c.66.1.25: mRNA cap methylase appears in the current release, SCOPe 2.08