Class c: Alpha and beta proteins (a/b) [51349] (141 folds) |
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily) 3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465 |
Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules |
Family c.36.1.10: TK-like PP module [88760] (2 proteins) different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain |
Protein Pyruvate dehydrogenase E1 component, PP module [88764] (1 species) E1A and E1B fused together in a single-chain protein |
Escherichia coli [TaxId:562] [88765] (6 PDB entries) |
Domain d1l8aa1: 1l8a A:56-470 [73677] Other proteins in same PDB: d1l8aa2, d1l8aa3, d1l8ab2, d1l8ab3 |
Domain d1l8ab1: 1l8a B:56-470 [73680] Other proteins in same PDB: d1l8aa2, d1l8aa3, d1l8ab2, d1l8ab3 complexed with mg, tdp |
Domain d1rp7a2: 1rp7 A:56-470 [97703] Other proteins in same PDB: d1rp7a1, d1rp7a3, d1rp7b1, d1rp7b3 |
Domain d1rp7b2: 1rp7 B:56-470 [97706] Other proteins in same PDB: d1rp7a1, d1rp7a3, d1rp7b1, d1rp7b3 complexed with mg, tzd |
Domain d2g25a2: 2g25 A:56-470 [134524] Other proteins in same PDB: d2g25a1, d2g25a3, d2g25b1, d2g25b3 automatically matched to d1l8aa1 complexed with mg, po4, tdk |
Domain d2g25b2: 2g25 B:56-470 [134527] Other proteins in same PDB: d2g25a1, d2g25a3, d2g25b1, d2g25b3 automatically matched to d1l8aa1 complexed with mg, po4, tdk |
Domain d2g28a2: 2g28 A:56-470 [134530] Other proteins in same PDB: d2g28a1, d2g28a3, d2g28b1, d2g28b3 automatically matched to d1l8aa1 complexed with mg, tdk |
Domain d2g28b2: 2g28 B:56-470 [134533] Other proteins in same PDB: d2g28a1, d2g28a3, d2g28b1, d2g28b3 automatically matched to d1l8aa1 complexed with mg, tdk |
Domain d2ieaa2: 2iea A:56-470 [137295] Other proteins in same PDB: d2ieaa1, d2ieaa3, d2ieab1, d2ieab3 automatically matched to d1l8aa1 complexed with mg, tdp |
Domain d2ieab2: 2iea B:56-470 [137298] Other proteins in same PDB: d2ieaa1, d2ieaa3, d2ieab1, d2ieab3 automatically matched to d1l8aa1 complexed with mg, tdp |
Timeline for Protein Pyruvate dehydrogenase E1 component, PP module from c.36.1.10: TK-like PP module: