SCOP 1.71: Protein: Transketolase (TK), PP module

Lineage for Protein: Transketolase (TK), PP module

Root: SCOP 1.71
Class c: Alpha and beta proteins (a/b) [51349] (134 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.10: TK-like PP module [88760] (2 proteins)
different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
Protein Transketolase (TK), PP module [88761] (4 species)

Species:

Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88762] (7 PDB entries)
1. Domains for 1ay0:
  1. Domain d1ay0a1: 1ay0 A:3-337 [31823]
    Other proteins in same PDB: d1ay0a2, d1ay0a3, d1ay0b2, d1ay0b3
  2. Domain d1ay0b1: 1ay0 B:3-337 [31825]
    Other proteins in same PDB: d1ay0a2, d1ay0a3, d1ay0b2, d1ay0b3
    complexed with ca, tpp; mutant
2. Domains for 1gpu:
  1. Domain d1gpua1: 1gpu A:3-337 [65454]
    Other proteins in same PDB: d1gpua2, d1gpua3, d1gpub2, d1gpub3
  2. Domain d1gpub1: 1gpu B:3-337 [65457]
    Other proteins in same PDB: d1gpua2, d1gpua3, d1gpub2, d1gpub3
    complexed with ca, thd
3. Domains for 1ngs:
  1. Domain d1ngsa1: 1ngs A:3-337 [31819]
    Other proteins in same PDB: d1ngsa2, d1ngsa3, d1ngsb2, d1ngsb3
  2. Domain d1ngsb1: 1ngs B:3-337 [31821]
    Other proteins in same PDB: d1ngsa2, d1ngsa3, d1ngsb2, d1ngsb3
    complexed with ca, e4p, tpp
4. Domains for 1tka:
  1. Domain d1tkaa1: 1tka A:3-337 [31815]
    Other proteins in same PDB: d1tkaa2, d1tkaa3, d1tkab2, d1tkab3
  2. Domain d1tkab1: 1tka B:3-337 [31817]
    Other proteins in same PDB: d1tkaa2, d1tkaa3, d1tkab2, d1tkab3
    complexed with ca, n3t
5. Domains for 1tkb:
  1. Domain d1tkba1: 1tkb A:3-337 [31807]
    Other proteins in same PDB: d1tkba2, d1tkba3, d1tkbb2, d1tkbb3
  2. Domain d1tkbb1: 1tkb B:3-337 [31809]
    Other proteins in same PDB: d1tkba2, d1tkba3, d1tkbb2, d1tkbb3
    complexed with ca, n1t
6. Domains for 1tkc:
  1. Domain d1tkca1: 1tkc A:3-337 [31811]
    Other proteins in same PDB: d1tkca2, d1tkca3, d1tkcb2, d1tkcb3
  2. Domain d1tkcb1: 1tkc B:3-337 [31813]
    Other proteins in same PDB: d1tkca2, d1tkca3, d1tkcb2, d1tkcb3
    complexed with ca, m6t
7. Domains for 1trk:
  1. Domain d1trka1: 1trk A:3-337 [31803]
    Other proteins in same PDB: d1trka2, d1trka3, d1trkb2, d1trkb3
  2. Domain d1trkb1: 1trk B:3-337 [31805]
    Other proteins in same PDB: d1trka2, d1trka3, d1trkb2, d1trkb3
    complexed with ca, tpp
Escherichia coli [TaxId:562] [89656] (1 PDB entry)
- Domains for 1qgd:
  1. Domain d1qgda2: 1qgd A:2-332 [88368]
    Other proteins in same PDB: d1qgda1, d1qgda3, d1qgdb1, d1qgdb3
  2. Domain d1qgdb2: 1qgd B:2-332 [88371]
    Other proteins in same PDB: d1qgda1, d1qgda3, d1qgdb1, d1qgdb3
    complexed with ca, so4, tpp
Leishmania mexicana mexicana [TaxId:44270] [117524] (1 PDB entry)
- Domains for 1r9j:
  1. Domain d1r9ja2: 1r9j A:1-336 [111723]
    Other proteins in same PDB: d1r9ja1, d1r9ja3, d1r9jb1, d1r9jb3
  2. Domain d1r9jb2: 1r9j B:1-336 [111726]
    Other proteins in same PDB: d1r9ja1, d1r9ja3, d1r9jb1, d1r9jb3
    complexed with ca, tpp
Maize (Zea mays) [TaxId:4577] [88763] (1 PDB entry)
- Domains for 1itz:
  1. Domain d1itza1: 1itz A:10-347 [76797]
    Other proteins in same PDB: d1itza2, d1itza3, d1itzb2, d1itzb3, d1itzc2, d1itzc3
  2. Domain d1itzb1: 1itz B:10-347 [76800]
    Other proteins in same PDB: d1itza2, d1itza3, d1itzb2, d1itzb3, d1itzc2, d1itzc3
  3. Domain d1itzc1: 1itz C:10-347 [76803]
    Other proteins in same PDB: d1itza2, d1itza3, d1itzb2, d1itzb3, d1itzc2, d1itzc3
    complexed with mg, tpp

More info for Protein Transketolase (TK), PP module from c.36.1.10: TK-like PP module

Timeline for Protein Transketolase (TK), PP module from c.36.1.10: TK-like PP module:

Protein Transketolase (TK), PP module from c.36.1.10: TK-like PP module first appeared in SCOP 1.65
Protein Transketolase (TK), PP module from c.36.1.10: TK-like PP module appears in SCOP 1.69
Protein Transketolase (TK), PP module from c.36.1.10: TK-like PP module appears in SCOP 1.73
Protein Transketolase (TK), PP module from c.36.1.10: TK-like PP module appears in the current release, SCOPe 2.08