SCOPe 2.05: Family c.36.1.10: TK-like PP module

Lineage for Family c.36.1.10: TK-like PP module

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.10: TK-like PP module [88760] (3 proteins)
   different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain

Proteins:

1. Pyruvate dehydrogenase E1 component, PP module [88764] (1 species)
   E1A and E1B fused together in a single-chain protein

   • Species Escherichia coli [TaxId:562] [88765] (8 PDB entries)

2. Transketolase (TK), PP module [88761] (4 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88762] (7 PDB entries)

   2. Species Escherichia coli [TaxId:562] [89656] (4 PDB entries)

   3. Species Leishmania mexicana mexicana [TaxId:44270] [117524] (1 PDB entry)
      Uniprot Q8MPM3

   4. Species Maize (Zea mays) [TaxId:4577] [88763] (1 PDB entry)

3. automated matches [254698] (1 species)
   not a true protein

   • Species Escherichia coli [TaxId:83334] [255937] (3 PDB entries)

More info for Family c.36.1.10: TK-like PP module

Timeline for Family c.36.1.10: TK-like PP module:

• Family c.36.1.10: TK-like PP module first appeared in SCOP 1.65
  
• Family c.36.1.10: TK-like PP module appears in SCOPe 2.04
  
• Family c.36.1.10: TK-like PP module appears in SCOPe 2.06
  
• Family c.36.1.10: TK-like PP module appears in the current release, SCOPe 2.08