Class c: Alpha and beta proteins (a/b) [51349] (141 folds) |
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily) 3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465 |
Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules |
Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (4 proteins) parent family to TK and PFOR heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module |
2-oxoisovalerate dehydrogenase (E1B), Pyr module [88744] (1 species) chain A is alpha-subunit and chain B is beta-subunit |
Species Pseudomonas putida [TaxId:303] [88745] (2 PDB entries) |
Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [88743] (21 PDB entries) |
Species Thermus thermophilus [TaxId:274] [102332] (4 PDB entries) |
E1-beta subunit of pyruvate dehydrogenase, Pyr module [69472] (2 species) |
Species Archaeon Pyrobaculum aerophilum [TaxId:13773] [69473] (1 PDB entry) |
Species Human (Homo sapiens) [TaxId:9606] [89653] (2 PDB entries) |
Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain [117522] (1 species) |
Species Bacillus stearothermophilus [TaxId:1422] [117523] (2 PDB entries) |
Timeline for Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module: