SCOPe 2.07: Protein: Pyruvate dehydrogenase E1 component, Pyr module

Lineage for Protein: Pyruvate dehydrogenase E1 component, Pyr module

Root: SCOPe 2.07
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)

there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

Family c.36.1.6: TK-like Pyr module [88735] (2 proteins)
different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
Protein Pyruvate dehydrogenase E1 component, Pyr module [88739] (1 species)
E1A and E1B fused together in a single-chain protein

Species:

Escherichia coli [TaxId:562] [88740] (6 PDB entries)
1. Domains for 1l8a:
  1. Domain d1l8aa2: 1l8a A:471-700 [73678]
    Other proteins in same PDB: d1l8aa1, d1l8aa3, d1l8ab1, d1l8ab3
    complexed with mg, tdp
  2. Domain d1l8ab2: 1l8a B:471-700 [73681]
    Other proteins in same PDB: d1l8aa1, d1l8aa3, d1l8ab1, d1l8ab3
    complexed with mg, tdp
2. Domains for 1rp7:
  1. Domain d1rp7a1: 1rp7 A:471-700 [97702]
    Other proteins in same PDB: d1rp7a2, d1rp7a3, d1rp7b2, d1rp7b3
    complexed with mg, tzd
  2. Domain d1rp7b1: 1rp7 B:471-700 [97705]
    Other proteins in same PDB: d1rp7a2, d1rp7a3, d1rp7b2, d1rp7b3
    complexed with mg, tzd
3. Domains for 2g25:
  1. Domain d2g25a1: 2g25 A:471-700 [134523]
    Other proteins in same PDB: d2g25a2, d2g25a3, d2g25b2, d2g25b3
    automated match to d1l8aa2
    complexed with mg, po4, tdk
  2. Domain d2g25b1: 2g25 B:471-700 [134526]
    Other proteins in same PDB: d2g25a2, d2g25a3, d2g25b2, d2g25b3
    automated match to d1l8aa2
    complexed with mg, po4, tdk
4. Domains for 2g28:
  1. Domain d2g28a1: 2g28 A:471-700 [134529]
    Other proteins in same PDB: d2g28a2, d2g28a3, d2g28b2, d2g28b3
    automated match to d1l8aa2
    complexed with mg, tdk
  2. Domain d2g28b1: 2g28 B:471-700 [134532]
    Other proteins in same PDB: d2g28a2, d2g28a3, d2g28b2, d2g28b3
    automated match to d1l8aa2
    complexed with mg, tdk
5. Domains for 2g67:
  1. Domain d2g67a1: 2g67 A:471-700 [134695]
    Other proteins in same PDB: d2g67a2, d2g67a3, d2g67b2, d2g67b3
    automated match to d1l8aa2
  2. Domain d2g67b1: 2g67 B:471-700 [134698]
    Other proteins in same PDB: d2g67a2, d2g67a3, d2g67b2, d2g67b3
    automated match to d1l8aa2
6. Domains for 2iea:
  1. Domain d2ieaa1: 2iea A:471-700 [137294]
    Other proteins in same PDB: d2ieaa2, d2ieaa3, d2ieab2, d2ieab3
    automated match to d1l8aa2
    complexed with mg, tdp
  2. Domain d2ieab1: 2iea B:471-700 [137297]
    Other proteins in same PDB: d2ieaa2, d2ieaa3, d2ieab2, d2ieab3
    automated match to d1l8aa2
    complexed with mg, tdp

More info for Protein Pyruvate dehydrogenase E1 component, Pyr module from c.36.1.6: TK-like Pyr module

Timeline for Protein Pyruvate dehydrogenase E1 component, Pyr module from c.36.1.6: TK-like Pyr module:

Protein Pyruvate dehydrogenase E1 component, Pyr module from c.36.1.6: TK-like Pyr module first appeared in SCOP 1.65
Protein Pyruvate dehydrogenase E1 component, Pyr module from c.36.1.6: TK-like Pyr module appears in SCOPe 2.06
Protein Pyruvate dehydrogenase E1 component, Pyr module from c.36.1.6: TK-like Pyr module appears in the current release, SCOPe 2.08