Lineage for Protein: Transketolase (TK), Pyr module

  1. Root: SCOP 1.71
  2. 570216Class c: Alpha and beta proteins (a/b) [51349] (134 folds)
  3. 581036Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 581037Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 581129Family c.36.1.6: TK-like Pyr module [88735] (2 proteins)
    different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
  6. 581136Protein Transketolase (TK), Pyr module [88736] (4 species)

Species:

  1. 581137Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88737] (7 PDB entries)
    1. Domains for 1ay0:
      1. 581150Domain d1ay0a2: 1ay0 A:338-534 [31824]
        Other proteins in same PDB: d1ay0a1, d1ay0a3, d1ay0b1, d1ay0b3
      2. 581151Domain d1ay0b2: 1ay0 B:338-534 [31826]
        Other proteins in same PDB: d1ay0a1, d1ay0a3, d1ay0b1, d1ay0b3
        complexed with ca, tpp; mutant
    2. Domains for 1gpu:
      1. 581138Domain d1gpua2: 1gpu A:338-534 [65455]
        Other proteins in same PDB: d1gpua1, d1gpua3, d1gpub1, d1gpub3
      2. 581139Domain d1gpub2: 1gpu B:338-534 [65458]
        Other proteins in same PDB: d1gpua1, d1gpua3, d1gpub1, d1gpub3
        complexed with ca, thd
    3. Domains for 1ngs:
      1. 581144Domain d1ngsa2: 1ngs A:338-534 [31820]
        Other proteins in same PDB: d1ngsa1, d1ngsa3, d1ngsb1, d1ngsb3
      2. 581145Domain d1ngsb2: 1ngs B:338-534 [31822]
        Other proteins in same PDB: d1ngsa1, d1ngsa3, d1ngsb1, d1ngsb3
        complexed with ca, e4p, tpp
    4. Domains for 1tka:
      1. 581146Domain d1tkaa2: 1tka A:338-534 [31816]
        Other proteins in same PDB: d1tkaa1, d1tkaa3, d1tkab1, d1tkab3
      2. 581147Domain d1tkab2: 1tka B:338-534 [31818]
        Other proteins in same PDB: d1tkaa1, d1tkaa3, d1tkab1, d1tkab3
        complexed with ca, n3t
    5. Domains for 1tkb:
      1. 581140Domain d1tkba2: 1tkb A:338-534 [31808]
        Other proteins in same PDB: d1tkba1, d1tkba3, d1tkbb1, d1tkbb3
      2. 581141Domain d1tkbb2: 1tkb B:338-534 [31810]
        Other proteins in same PDB: d1tkba1, d1tkba3, d1tkbb1, d1tkbb3
        complexed with ca, n1t
    6. Domains for 1tkc:
      1. 581148Domain d1tkca2: 1tkc A:338-534 [31812]
        Other proteins in same PDB: d1tkca1, d1tkca3, d1tkcb1, d1tkcb3
      2. 581149Domain d1tkcb2: 1tkc B:338-534 [31814]
        Other proteins in same PDB: d1tkca1, d1tkca3, d1tkcb1, d1tkcb3
        complexed with ca, m6t
    7. Domains for 1trk:
      1. 581142Domain d1trka2: 1trk A:338-534 [31804]
        Other proteins in same PDB: d1trka1, d1trka3, d1trkb1, d1trkb3
      2. 581143Domain d1trkb2: 1trk B:338-534 [31806]
        Other proteins in same PDB: d1trka1, d1trka3, d1trkb1, d1trkb3
        complexed with ca, tpp
  2. 581152Escherichia coli [TaxId:562] [89650] (1 PDB entry)
  3. 581155Leishmania mexicana mexicana [TaxId:44270] [117521] (1 PDB entry)
  4. 581158Maize (Zea mays) [TaxId:4577] [88738] (1 PDB entry)

More info for Protein Transketolase (TK), Pyr module from c.36.1.6: TK-like Pyr module

Timeline for Protein Transketolase (TK), Pyr module from c.36.1.6: TK-like Pyr module: