Lineage for Protein: Acetohydroxyacid synthase catalytic subunit

  1. Root: SCOPe 2.05
  2. 1815291Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 1844143Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 1844144Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 1844145Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (8 proteins)
    the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology
    automatically mapped to Pfam PF02776
  6. 1844146Protein Acetohydroxyacid synthase catalytic subunit [88733] (2 species)

Species:

  1. 1844147Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88734] (6 PDB entries)
    Uniprot P07342 84-687
    1. Domains for 1jsc:
      1. 1844158Domain d1jsca2: 1jsc A:83-270 [67225]
        Other proteins in same PDB: d1jsca1, d1jsca3, d1jscb1, d1jscb3
        complexed with 2hp, fad, k, mg, tpp
      2. 1844159Domain d1jscb2: 1jsc B:82-272 [67228]
        Other proteins in same PDB: d1jsca1, d1jsca3, d1jscb1, d1jscb3
        complexed with 2hp, fad, k, mg, tpp
    2. Domains for 1n0h:
      1. 1844160Domain d1n0ha2: 1n0h A:83-270 [79735]
        Other proteins in same PDB: d1n0ha1, d1n0ha3, d1n0hb1, d1n0hb3
        complexed with ayd, cie, dtt, fad, k, mg, tpp
      2. 1844161Domain d1n0hb2: 1n0h B:83-270 [79738]
        Other proteins in same PDB: d1n0ha1, d1n0ha3, d1n0hb1, d1n0hb3
        complexed with ayd, cie, dtt, fad, k, mg, tpp
    3. Domains for 1t9a:
      1. 1844156Domain d1t9aa2: 1t9a A:89-263 [112329]
        Other proteins in same PDB: d1t9aa1, d1t9aa3, d1t9ab1, d1t9ab3
        complexed with 1tb, fad, k, mg, p23, yf3, yf4
      2. 1844157Domain d1t9ab2: 1t9a B:89-263 [112332]
        Other proteins in same PDB: d1t9aa1, d1t9aa3, d1t9ab1, d1t9ab3
        complexed with 1tb, fad, k, mg, p23, yf3, yf4
    4. Domains for 1t9b:
      1. 1844148Domain d1t9ba2: 1t9b A:89-263 [112335]
        Other proteins in same PDB: d1t9ba1, d1t9ba3, d1t9bb1, d1t9bb3
        complexed with 1cs, fad, k, mg, nsp, p22, p25, yf3
      2. 1844149Domain d1t9bb2: 1t9b B:89-263 [112338]
        Other proteins in same PDB: d1t9ba1, d1t9ba3, d1t9bb1, d1t9bb3
        complexed with 1cs, fad, k, mg, nsp, p22, p25, yf3
    5. Domains for 1t9c:
      1. 1844154Domain d1t9ca2: 1t9c A:89-263 [112341]
        Other proteins in same PDB: d1t9ca1, d1t9ca3, d1t9cb1, d1t9cb3
        complexed with 1sm, fad, k, mg, p22, p23
      2. 1844155Domain d1t9cb2: 1t9c B:89-263 [112344]
        Other proteins in same PDB: d1t9ca1, d1t9ca3, d1t9cb1, d1t9cb3
        complexed with 1sm, fad, k, mg, p22, p23
    6. Domains for 1t9d:
      1. 1844150Domain d1t9da2: 1t9d A:89-263 [112347]
        Other proteins in same PDB: d1t9da1, d1t9da3, d1t9db1, d1t9db3, d1t9dc1, d1t9dc3, d1t9dd1, d1t9dd3
        complexed with 1mm, fad, k, mg, p22, p25, pyd
      2. 1844151Domain d1t9db2: 1t9d B:89-263 [112350]
        Other proteins in same PDB: d1t9da1, d1t9da3, d1t9db1, d1t9db3, d1t9dc1, d1t9dc3, d1t9dd1, d1t9dd3
        complexed with 1mm, fad, k, mg, p22, p25, pyd
      3. 1844152Domain d1t9dc2: 1t9d C:89-263 [112353]
        Other proteins in same PDB: d1t9da1, d1t9da3, d1t9db1, d1t9db3, d1t9dc1, d1t9dc3, d1t9dd1, d1t9dd3
        complexed with 1mm, fad, k, mg, p22, p25, pyd
      4. 1844153Domain d1t9dd2: 1t9d D:89-263 [112356]
        Other proteins in same PDB: d1t9da1, d1t9da3, d1t9db1, d1t9db3, d1t9dc1, d1t9dc3, d1t9dd1, d1t9dd3
        complexed with 1mm, fad, k, mg, p22, p25, pyd
  2. 1844162Thale cress (Arabidopsis thaliana), chloroplast [TaxId:3702] [142204] (6 PDB entries)
    Uniprot P17597 86-280
    1. Domain for 1ybh:
    2. Domain for 1yhy:
    3. Domain for 1yhz:
    4. Domain for 1yi0:
    5. Domain for 1yi1:
    6. Domain for 1z8n:

More info for Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module

Timeline for Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module:

  • Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module first appeared in SCOP 1.65
  • Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in SCOPe 2.04
  • Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in SCOPe 2.06
  • Protein Acetohydroxyacid synthase catalytic subunit from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in the current release, SCOPe 2.07