Lineage for Protein: Pyruvate oxidase

  1. Root: SCOPe 2.05
  2. 1815291Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 1844143Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 1844144Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 1844145Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (8 proteins)
    the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology
    automatically mapped to Pfam PF02776
  6. 1844265Protein Pyruvate oxidase [88729] (2 species)

Species:

  1. 1844266Aerococcus viridans [TaxId:1377] [142203] (2 PDB entries)
    1. Domain for 1v5e:
    2. Domain for 2dji:
  2. Lactobacillus plantarum [TaxId:1590] [88730] (2 PDB entries)
    1. Domains for 1pow:
      1. 1844272Domain d1powa2: 1pow A:9-182 [31797]
        Other proteins in same PDB: d1powa1, d1powa3, d1powb1, d1powb3
        complexed with fad, mg, tpp; mutant
      2. 1844273Domain d1powb2: 1pow B:9-182 [31799]
        Other proteins in same PDB: d1powa1, d1powa3, d1powb1, d1powb3
        complexed with fad, mg, tpp; mutant
    2. Domains for 1pox:
      1. 1844270Domain d1poxa2: 1pox A:9-182 [31793]
        Other proteins in same PDB: d1poxa1, d1poxa3, d1poxb1, d1poxb3
        complexed with fad, gol, mg, na, tpp; mutant
      2. 1844271Domain d1poxb2: 1pox B:9-182 [31795]
        Other proteins in same PDB: d1poxa1, d1poxa3, d1poxb1, d1poxb3
        complexed with fad, gol, mg, na, tpp; mutant

More info for Protein Pyruvate oxidase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module

Timeline for Protein Pyruvate oxidase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module: