![]() | Class c: Alpha and beta proteins (a/b) [51349] (134 folds) |
![]() | Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily) 3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465 |
![]() | Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) ![]() there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules |
![]() | Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (7 proteins) the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology |
![]() | Protein Pyruvate decarboxylase [88725] (3 species) |
![]() | Species Brewer's yeast (Saccharomyces), uvarum strain [TaxId:230603] [88726] (1 PDB entry) |
![]() | Domain d1pyda2: 1pyd A:2-181 [31773] Other proteins in same PDB: d1pyda1, d1pyda3, d1pydb1, d1pydb3 |
![]() | Domain d1pydb2: 1pyd B:2-181 [31775] Other proteins in same PDB: d1pyda1, d1pyda3, d1pydb1, d1pydb3 complexed with mg, tdp |
Timeline for Species Brewer's yeast (Saccharomyces), uvarum strain [TaxId:230603] from c.36.1.5 Pyruvate decarboxylase: