Lineage for Protein: Pyruvate decarboxylase

  1. Root: SCOP 1.65
  2. 305035Class c: Alpha and beta proteins (a/b) [51349] (121 folds)
  3. 312976Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 312977Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 312978Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (5 proteins)
    the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology
  6. 313010Protein Pyruvate decarboxylase [88725] (3 species)

Species:

  1. 313011Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88727] (2 PDB entries)
    1. Domains for 1pvd:
      1. 313012Domain d1pvda2: 1pvd A:2-181 [31777]
        Other proteins in same PDB: d1pvda1, d1pvda3, d1pvdb1, d1pvdb3
      2. 313013Domain d1pvdb2: 1pvd B:2-181 [31779]
        Other proteins in same PDB: d1pvda1, d1pvda3, d1pvdb1, d1pvdb3
        complexed with mg, tpp
    2. Domains for 1qpb:
      1. 313014Domain d1qpba2: 1qpb A:2-181 [31781]
        Other proteins in same PDB: d1qpba1, d1qpba3, d1qpbb1, d1qpbb3
      2. 313015Domain d1qpbb2: 1qpb B:2-181 [31783]
        Other proteins in same PDB: d1qpba1, d1qpba3, d1qpbb1, d1qpbb3
  2. 313016Brewer's yeast (Saccharomyces), uvarum strain [TaxId:230603] [88726] (1 PDB entry)
  3. 313019Zymomonas mobilis [TaxId:542] [88728] (1 PDB entry)

More info for Protein Pyruvate decarboxylase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module

Timeline for Protein Pyruvate decarboxylase from c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module: