SCOPe 2.08: Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module

Lineage for Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (8 proteins)
   the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology
   automatically mapped to Pfam PF02776

Proteins:

1. Acetohydroxyacid synthase catalytic subunit [88733] (3 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88734] (8 PDB entries)
      Uniprot P07342 84-687

   2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [314106] (3 PDB entries)

   3. Species Thale cress (Arabidopsis thaliana), chloroplast [TaxId:3702] [142204] (12 PDB entries)
      Uniprot P17597 86-280

2. Benzoylformate decarboxylase [88731] (1 species)

   • Species Pseudomonas putida [TaxId:303] [88732] (7 PDB entries)
     Uniprot P20906

3. Carboxyethylarginine synthase [102330] (1 species)

   • Species Streptomyces clavuligerus [TaxId:1901] [102331] (6 PDB entries)

4. Catabolic acetolactate synthase [102328] (1 species)

   • Species Klebsiella pneumoniae [TaxId:573] [102329] (3 PDB entries)

5. Indole-3-pyruvate decarboxylase [89648] (1 species)

   • Species Enterobacter cloacae [TaxId:550] [89649] (1 PDB entry)

6. Oxalyl-CoA decarboxylase [142205] (1 species)

   • Species Oxalobacter formigenes [TaxId:847] [142206] (6 PDB entries)
     Uniprot P40149 7-194

7. Pyruvate decarboxylase [88725] (3 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88727] (2 PDB entries)

   2. Species Brewer's yeast (Saccharomyces uvarum) [TaxId:230603] [88726] (1 PDB entry)

   3. Species Zymomonas mobilis [TaxId:542] [88728] (1 PDB entry)

8. Pyruvate oxidase [88729] (2 species)

   1. Species Aerococcus viridans [TaxId:1377] [142203] (2 PDB entries)

   2. Species Lactobacillus plantarum [TaxId:1590] [88730] (2 PDB entries)

More info for Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module

Timeline for Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module:

• Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module first appeared in SCOP 1.65
  
• Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module appears in SCOPe 2.07