SCOPe 2.05: Family c.1.12.7: Phosphoenolpyruvate mutase/Isocitrate lyase-like

Lineage for Family c.1.12.7: Phosphoenolpyruvate mutase/Isocitrate lyase-like

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.12: Phosphoenolpyruvate/pyruvate domain [51621] (8 families)

5. Family c.1.12.7: Phosphoenolpyruvate mutase/Isocitrate lyase-like [88704] (4 proteins)
   forms a swapped dimer

Proteins:

1. 2-methylisocitrate lyase [89499] (2 species)

   1. Species Escherichia coli [TaxId:562] [89500] (4 PDB entries)

   2. Species Salmonella typhimurium [TaxId:90371] [102099] (2 PDB entries)

2. Isocitrate lyase [51642] (3 species)
   elaborated with additional subdomains

   1. Species Emericella nidulans (Aspergillus nidulans) [TaxId:162425] [51643] (1 PDB entry)

   2. Species Escherichia coli [TaxId:562] [63923] (1 PDB entry)

   3. Species Mycobacterium tuberculosis [TaxId:1773] [51644] (3 PDB entries)

3. Phosphoenolpyruvate mutase [51636] (1 species)

   • Species Blue mussel (Mytilus edulis) [TaxId:6550] [51637] (6 PDB entries)

4. automated matches [190974] (3 species)
   not a true protein

   1. Species Burkholderia pseudomallei [TaxId:28450] [225729] (1 PDB entry)

   2. Species Burkholderia pseudomallei [TaxId:331109] [188638] (1 PDB entry)

   3. Species Yersinia pestis [TaxId:632] [189309] (1 PDB entry)

More info for Family c.1.12.7: Phosphoenolpyruvate mutase/Isocitrate lyase-like

Timeline for Family c.1.12.7: Phosphoenolpyruvate mutase/Isocitrate lyase-like:

• Family c.1.12.7: Phosphoenolpyruvate mutase/Isocitrate lyase-like first appeared in SCOP 1.65
  
• Family c.1.12.7: Phosphoenolpyruvate mutase/Isocitrate lyase-like appears in SCOPe 2.04
  
• Family c.1.12.7: Phosphoenolpyruvate mutase/Isocitrate lyase-like appears in SCOPe 2.06
  
• Family c.1.12.7: Phosphoenolpyruvate mutase/Isocitrate lyase-like appears in the current release, SCOPe 2.08