SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family b.121.4.1: Picornaviridae-like VP (VP1, VP2, VP3 and VP4)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2075417Fold b.121: Nucleoplasmin-like/VP (viral coat and capsid proteins) [88632] (7 superfamilies)
    sandwich; 8 strands in 2 sheets; jelly-roll; some members can have additional 1-2 strands
    characteristic interaction between the domains of this fold allows the formation of five-fold and pseudo six-fold assemblies
  4. 2075626Superfamily b.121.4: Positive stranded ssRNA viruses [88633] (10 families) (S)
  5. 2075627Family b.121.4.1: Picornaviridae-like VP (VP1, VP2, VP3 and VP4) [88634] (10 protein domains)
    the order of the chains N-VP0-VP3-VP1-C is as in the polyprotein; VP0 is cleaved later upon capsid assembly to VP4 and VP2
    there is a different order in the shuffled genome of insect picorna-like proteins (Cricket paralysis virus)

Protein Domains:

  1. 2075628Aphthovirus (Foot-and-mouth disease virus) coat proteins [49659] (1 species)
  2. 2075642Bovine enterovirus coat proteins [49676] (1 species)
  3. 2075647Human enterovirus B coat proteins [88635] (4 species)
    1. 2075648Species Human coxsackievirus A9 [TaxId:12067] [49683] (1 PDB entry)
    2. 2075652Species Human coxsackievirus B3 [TaxId:12072] [49681] (2 PDB entries)
    3. 2075657Species Human echovirus 1 [TaxId:46633] [49685] (1 PDB entry)
    4. 2075661Species Human echovirus 11 [TaxId:12078] [74890] (3 PDB entries)
  4. 2075670Insect picorna-like virus coat proteins [49654] (1 species)
    different genetic order of VP segments due to extensive genome shuffling
  5. 2075675Mengo encephalomyocarditis virus coat proteins [49678] (1 species)
  6. 2075683Poliovirus coat proteins [49666] (3 species)
    1. 2075684Species Poliovirus type 1, strain Mahoney [TaxId:12080] [49667] (12 PDB entries)
    2. 2075719Species Poliovirus type 2, strain Lansing [TaxId:12083] [49668] (1 PDB entry)
    3. 2075723Species Poliovirus type 3, strain Sabin [TaxId:12086] [49669] (7 PDB entries)
  7. 2075745Rhinovirus coat proteins [49670] (5 species)
    1. 2075746Species Human rhinovirus 16, (HRV-16) [TaxId:31708] [49672] (9 PDB entries)
    2. 2075774Species Human rhinovirus 3, (HRV-3) [TaxId:44130] [49675] (1 PDB entry)
    3. 2075778Species Human rhinovirus A 1A (HRV-1A) [TaxId:12134] [49673] (4 PDB entries)
    4. 2075791Species Human rhinovirus A 2 (HRV-2) [TaxId:12130] [49674] (2 PDB entries)
    5. 2075798Species Human rhinovirus B 14 (HRV-14) [TaxId:12131] [49671] (30 PDB entries)
  8. 2075889Swine vesicular disease virus coat proteins [89225] (1 species)
  9. 2075897Theilovirus capsid proteins [49686] (1 species)
  10. 2075905automated matches [190854] (13 species)
    not a true protein
    1. 2075906Species Coxsackievirus a16 (strain tainan/5079/98) [TaxId:231417] [277504] (1 PDB entry)
    2. 2075908Species Coxsackievirus a16 [TaxId:31704] [276274] (3 PDB entries)
    3. 2075912Species Coxsackievirus a24 [TaxId:12089] [260750] (4 PDB entries)
    4. 2075921Species Foot-and-mouth disease virus - type a [TaxId:12111] [196861] (4 PDB entries)
    5. 2075930Species Foot-and-mouth disease virus [TaxId:12110] [188180] (3 PDB entries)
    6. 2075935Species Foot-and-mouth disease virus [TaxId:12122] [255673] (1 PDB entry)
    7. 2075937Species Human coxsackievirus B3 [TaxId:12072] [194627] (1 PDB entry)
    8. 2075939Species Human echovirus 7 [TaxId:46018] [255678] (1 PDB entry)
    9. 2075942Species Human enterovirus 71 [TaxId:39054] [195913] (11 PDB entries)
    10. 2075962Species Human rhinovirus 14 [TaxId:12131] [258112] (1 PDB entry)
    11. 2075965Species Human rhinovirus 2 [TaxId:12130] [256100] (1 PDB entry)
    12. 2275067Species Saffold virus [TaxId:434309] [318368] (2 PDB entries)
    13. 2292138Species Foot-and-mouth disease virus - type o [TaxId:12118] [335439] (1 PDB entry)

More info for Family b.121.4.1: Picornaviridae-like VP (VP1, VP2, VP3 and VP4)

Timeline for Family b.121.4.1: Picornaviridae-like VP (VP1, VP2, VP3 and VP4):