![]() | Class b: All beta proteins [48724] (126 folds) |
![]() | Fold b.1: Immunoglobulin-like beta-sandwich [48725] (20 superfamilies) sandwich; 7 strands in 2 sheets; greek-key some members of the fold have additional strands |
![]() | Superfamily b.1.1: Immunoglobulin [48726] (4 families) ![]() |
![]() | Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (21 proteins) |
![]() | Protein Immunoglobulin heavy chain variable domain, VH [88543] (19 species) VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogeneous CDRs are listed as engineered species |
![]() | Species Engineered (including hybrid species) [88562] (24 PDB entries) |
![]() | Domain d1b2wh1: 1b2w H:1-117 [20307] Other proteins in same PDB: d1b2wh2, d1b2wl1, d1b2wl2 part of a humanized anti-gamma-interferon Fab |
![]() | Domain d1bvkb_: 1bvk B: [20279] Other proteins in same PDB: d1bvka_, d1bvkc_, d1bvkd_, d1bvkf_ |
![]() | Domain d1bvke_: 1bvk E: [20281] Other proteins in same PDB: d1bvka_, d1bvkc_, d1bvkd_, d1bvkf_ part of humanized anti-lysozyme Fv HuLys11 |
![]() | Domain d1bvla_: 1bvl A: [20282] Other proteins in same PDB: d1bvlb_, d1bvld_ |
![]() | Domain d1bvlc_: 1bvl C: [20284] Other proteins in same PDB: d1bvlb_, d1bvld_ part of humanized anti-lysozyme Fv HuLys11 |
![]() | Domain d1fgvh_: 1fgv H: [19853] Other proteins in same PDB: d1fgvl_ part of humanized Fv H52 |
![]() | Domain d1fvcb_: 1fvc B: [19863] Other proteins in same PDB: d1fvca_, d1fvcc_ |
![]() | Domain d1fvcd_: 1fvc D: [19865] Other proteins in same PDB: d1fvca_, d1fvcc_ part of humanized Fv 4D5, herceptin |
![]() | Domain d1i9rh1: 1i9r H:1-118 [71151] Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh2, d1i9rk2, d1i9rl1, d1i9rl2, d1i9rm1, d1i9rm2, d1i9rx2, d1i9ry1, d1i9ry2 |
![]() | Domain d1i9rk1: 1i9r K:1-118 [71153] Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh2, d1i9rk2, d1i9rl1, d1i9rl2, d1i9rm1, d1i9rm2, d1i9rx2, d1i9ry1, d1i9ry2 |
![]() | Domain d1i9rx1: 1i9r X:1-118 [71159] Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh2, d1i9rk2, d1i9rl1, d1i9rl2, d1i9rm1, d1i9rm2, d1i9rx2, d1i9ry1, d1i9ry2 complexed with zn |
![]() | Domain d1it9h1: 1it9 H:1-121 [76783] Other proteins in same PDB: d1it9h2, d1it9l1, d1it9l2 part of humanized anti-human Fas Fab HFE7A |
![]() | Domain d1jpth1: 1jpt H:1-117 [67051] Other proteins in same PDB: d1jpth2, d1jptl1, d1jptl2 part of humanized Fab D3H44 against human tissue factor |
![]() | Domain d1l7ih1: 1l7i H:1-113 [73656] Other proteins in same PDB: d1l7ih2, d1l7il1, d1l7il2 part of humanized anti-ERBb2 Fab 2C4 complexed with so4 |
![]() | Domain d1mhph1: 1mhp H:1-118 [84967] Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph2, d1mhpl1, d1mhpl2, d1mhpy_ part of humanized anti-alpha1 integrin I-domain Fab complexed with mn; mutant |
![]() | Domain d1mhpx_: 1mhp X: [84971] Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph2, d1mhpl1, d1mhpl2, d1mhpy_ part of humanized anti-alpha1 integrin I-domain Fab; only V domain is ordered complexed with mn; mutant |
![]() | Domain d1vhp__: 1vhp - [20504] camelized monomeric VH |
![]() | Domain d2f5ah1: 2f5a H:1-132 [88502] Other proteins in same PDB: d2f5ah2, d2f5al1, d2f5al2 part of humanized HIV-1 neutralizing Fab 2F5 |
![]() | Domain d2f5bh1: 2f5b H:1-132 [88506] Other proteins in same PDB: d2f5bh2, d2f5bl1, d2f5bl2 part of humanized HIV-1 neutralizing Fab 2F5 |
![]() | Domain d2fgwh1: 2fgw H:1-124 [19855] Other proteins in same PDB: d2fgwh2, d2fgwl1, d2fgwl2 part of humanized Fab H52 |
Timeline for Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin heavy chain variable domain, VH: