Class b: All beta proteins [48724] (176 folds) |
Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies) sandwich; 7 strands in 2 sheets; greek-key some members of the fold have additional strands |
Superfamily b.1.1: Immunoglobulin [48726] (5 families) |
Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins) |
Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species) VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species |
Species Mouse (Mus musculus), cluster 3.1 [TaxId:10090] [88551] (31 PDB entries) SQ NA # natural chimera; best hits are: Uniprot P01751 (Ig heavy chain V region B1-8/186-2) and Uniprot P01864 (Ig gamma-2A chain C region secreted form) |
Domain d12e8h1: 12e8 H:1-114 [20269] Other proteins in same PDB: d12e8h2, d12e8l1, d12e8l2, d12e8m1, d12e8m2, d12e8p2 part of Fab 2E8 specific to the low density lipoprotein receptor binding region of apolipoprotein E |
Domain d12e8p1: 12e8 P:1-114 [20271] Other proteins in same PDB: d12e8h2, d12e8l1, d12e8l2, d12e8m1, d12e8m2, d12e8p2 part of Fab 2E8 specific to the low density lipoprotein receptor binding region of apolipoprotein E |
Domain d15c8h1: 15c8 H:1-113 [20301] Other proteins in same PDB: d15c8h2, d15c8l1, d15c8l2 part of catalytic Fab 5C8 |
Domain d1a3rh1: 1a3r H:2-119 [19781] Other proteins in same PDB: d1a3rh2, d1a3rl1, d1a3rl2 part of Fab 8F5 |
Domain d1a5fh1: 1a5f H:1-120 [20303] Other proteins in same PDB: d1a5fh2, d1a5fl1, d1a5fl2 part of an anti-E-selectin Fab |
Domain d1ahwb1: 1ahw B:1-117 [20219] Other proteins in same PDB: d1ahwa1, d1ahwa2, d1ahwb2, d1ahwc1, d1ahwc2, d1ahwd1, d1ahwd2, d1ahwe2, d1ahwf1, d1ahwf2 part of anti-human tissue factor Fab 5G9 |
Domain d1ahwe1: 1ahw E:1-117 [20221] Other proteins in same PDB: d1ahwa1, d1ahwa2, d1ahwb2, d1ahwc1, d1ahwc2, d1ahwd1, d1ahwd2, d1ahwe2, d1ahwf1, d1ahwf2 part of anti-human tissue factor Fab 5G9 |
Domain d1aj7h1: 1aj7 H:1-114 [20085] Other proteins in same PDB: d1aj7h2, d1aj7l1, d1aj7l2 part of humanized Fab 48G7 complexed with npe |
Domain d1ap2b_: 1ap2 B: [20183] Other proteins in same PDB: d1ap2a_, d1ap2c_ part of P-glycoprotein-specific scFv C219 |
Domain d1ap2d_: 1ap2 D: [20185] Other proteins in same PDB: d1ap2a_, d1ap2c_ part of P-glycoprotein-specific scFv C219 |
Domain d1bbdh1: 1bbd H:1-119 [19783] Other proteins in same PDB: d1bbdh2, d1bbdl1, d1bbdl2 part of Fab 8F5 complexed with so4 |
Domain d1cr9h1: 1cr9 H:1-110 [20431] Other proteins in same PDB: d1cr9h2, d1cr9l1, d1cr9l2 part of anti-prion Fab 3F4 |
Domain d1cu4h1: 1cu4 H:3-110 [20433] Other proteins in same PDB: d1cu4h2, d1cu4l1, d1cu4l2 part of anti-prion Fab 3F4 |
Domain d1dvfd_: 1dvf D: [20107] Other proteins in same PDB: d1dvfa_, d1dvfc_ part of Fv E5.2, anti-idiotopic antibody to D1.3 CASP1 complexed with zn |
Domain d1dzba1: 1dzb A:1-117 [20488] Other proteins in same PDB: d1dzba2, d1dzbb2, d1dzbx_, d1dzby_ part of anti-lysozyme scFv 1F9 |
Domain d1dzbb1: 1dzb B:1-117 [20490] Other proteins in same PDB: d1dzba2, d1dzbb2, d1dzbx_, d1dzby_ part of anti-lysozyme scFv 1F9 |
Domain d1fgnh1: 1fgn H:1-117 [20217] Other proteins in same PDB: d1fgnh2, d1fgnl1, d1fgnl2 part of anti-human tissue factor Fab 5G9 |
Domain d1gafh1: 1gaf H:1-114 [20083] Other proteins in same PDB: d1gafh2, d1gafl1, d1gafl2 part of humanized Fab 48G7 complexed with npe |
Domain d1hklh1: 1hkl H:1-114 [20089] Other proteins in same PDB: d1hklh2, d1hkll1, d1hkll2 part of humanized Fab 48G7 |
Domain d1il1a1: 1il1 A:3-121 [62539] Other proteins in same PDB: d1il1a2, d1il1b1, d1il1b2 part of anti-HIV Fab G3-519 |
Domain d1jnlh1: 1jnl H:1-114 [66956] Other proteins in same PDB: d1jnlh2, d1jnll1, d1jnll2 part of anti-estradiol Fab 17E12E5 |
Domain d1jnnh1: 1jnn H:1-114 [66960] Other proteins in same PDB: d1jnnh2, d1jnnl1, d1jnnl2 part of anti-estradiol Fab 17E12E5 complexed with est |
Domain d1k6qh1: 1k6q H:1-117 [72092] Other proteins in same PDB: d1k6qh2, d1k6ql1, d1k6ql2 part of anti-human tissue factor Fab D3 |
Domain d1moea2: 1moe A:120-240 [85031] Other proteins in same PDB: d1moea1, d1moeb1 part of anti-CEA scFv T84.66; VL to VH linkage: linker residues 112-119; assembles as a diabody complexed with so4 |
Domain d1moeb2: 1moe B:120-240 [85033] Other proteins in same PDB: d1moea1, d1moeb1 part of anti-CEA scFv T84.66; VL to VH linkage: linker residues 112-119; assembles as a diabody complexed with so4 |
Domain d1qblh1: 1qbl H:1-112 [20363] Other proteins in same PDB: d1qblh2, d1qbll1, d1qbll2 part of anti-cytochrome c Fab E8 |
Domain d1qbmh1: 1qbm H:1-112 [20365] Other proteins in same PDB: d1qbmh2, d1qbml1, d1qbml2 part of anti-cytochrome c Fab E8 |
Domain d1qoka1: 1qok A:27-147 [20492] Other proteins in same PDB: d1qoka2 part of anti-carcinoembryonic scFv MFE-23 |
Domain d1wejh1: 1wej H:1-112 [20361] Other proteins in same PDB: d1wejf_, d1wejh2, d1wejl1, d1wejl2 part of anti-cytochrome c Fab E8 complexed with hem, zn |
Domain d25c8h1: 25c8 H:1-113 [20299] Other proteins in same PDB: d25c8h2, d25c8l1, d25c8l2 part of catalytic Fab 5C8 complexed with gep |
Domain d2ap2b_: 2ap2 B: [20179] Other proteins in same PDB: d2ap2a_, d2ap2c_ part of P-glycoprotein-specific scFv C219 |
Domain d2ap2d_: 2ap2 D: [20181] Other proteins in same PDB: d2ap2a_, d2ap2c_ part of P-glycoprotein-specific scFv C219 |
Domain d2bdnh1: 2bdn H:1-117 [144985] Other proteins in same PDB: d2bdna1, d2bdnh2 |
Domain d2gsib1: 2gsi B:2-114 [145221] Other proteins in same PDB: d2gsia1, d2gsia2, d2gsib2, d2gsic1, d2gsic2, d2gsid2, d2gsie1, d2gsie2, d2gsif2, d2gsig1, d2gsig2, d2gsih2 complexed with na |
Domain d2gsid1: 2gsi D:2-114 [145223] Other proteins in same PDB: d2gsia1, d2gsia2, d2gsib2, d2gsic1, d2gsic2, d2gsid2, d2gsie1, d2gsie2, d2gsif2, d2gsig1, d2gsig2, d2gsih2 automatically matched to 2GSI B:2-114 complexed with na |
Domain d2gsif1: 2gsi F:2-114 [145225] Other proteins in same PDB: d2gsia1, d2gsia2, d2gsib2, d2gsic1, d2gsic2, d2gsid2, d2gsie1, d2gsie2, d2gsif2, d2gsig1, d2gsig2, d2gsih2 automatically matched to 2GSI B:2-114 complexed with na |
Domain d2gsih1: 2gsi H:2-114 [145227] Other proteins in same PDB: d2gsia1, d2gsia2, d2gsib2, d2gsic1, d2gsic2, d2gsid2, d2gsie1, d2gsie2, d2gsif2, d2gsig1, d2gsig2, d2gsih2 automatically matched to 2GSI B:2-114 complexed with na |
Domain d2hh0h1: 2hh0 H:1-149 [136462] Other proteins in same PDB: d2hh0h2, d2hh0l1, d2hh0l2 |
Domain d2rcsh1: 2rcs H:1-114 [20087] Other proteins in same PDB: d2rcsh2, d2rcsl1, d2rcsl2 part of humanized Fab 48G7 |
Domain d35c8h1: 35c8 H:1-113 [20297] Other proteins in same PDB: d35c8h2, d35c8l1, d35c8l2 part of catalytic Fab 5C8 complexed with nox |
Timeline for Species Mouse (Mus musculus), cluster 3.1 [TaxId:10090] from b.1.1.1 Immunoglobulin heavy chain variable domain, VH: