Lineage for Protein: Immunoglobulin light chain lambda variable domain, VL-lambda

  1. Root: SCOP 1.65
  2. 287094Class b: All beta proteins [48724] (126 folds)
  3. 287095Fold b.1: Immunoglobulin-like beta-sandwich [48725] (20 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 287096Superfamily b.1.1: Immunoglobulin [48726] (4 families) (S)
  5. 287097Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (21 proteins)
  6. 288276Protein Immunoglobulin light chain lambda variable domain, VL-lambda [88534] (8 species)
    VL-lambda domains of human antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the human genome; mouse VL-lambda domains belong to a single germline family

Species:

  1. 288277Hamster (Cricetulus griseus) [TaxId:10029] [88542] (1 PDB entry)
  2. 288280Human (Homo sapiens), cluster 1 [TaxId:9606] [88535] (2 PDB entries)
    1. Domains for 1cd0:
      1. 288281Domain d1cd0a_: 1cd0 A: [20559]
      2. 288282Domain d1cd0b_: 1cd0 B: [20560]
        VL dimer of Bence-Jones protein JTO
    2. Domains for 2cd0:
      1. 288283Domain d2cd0a_: 2cd0 A: [20561]
      2. 288284Domain d2cd0b_: 2cd0 B: [20562]
        VL dimer of Bence-Jones protein WIL
  3. 288285Human (Homo sapiens), cluster 2 [TaxId:9606] [88536] (6 PDB entries)
    1. Domains for 1bjm:
      1. 288288Domain d1bjma1: 1bjm A:1-111 [20524]
        Other proteins in same PDB: d1bjma2, d1bjmb2
      2. 288289Domain d1bjmb1: 1bjm B:1-111 [20525]
        Other proteins in same PDB: d1bjma2, d1bjmb2
        VL dimer of Bence-Jones protein LOC
    2. Domain for 2fb4:
    3. Domain for 2ig2:
    4. Domain for 2rhe:
    5. Domains for 3bjl:
      1. 288290Domain d3bjla1: 3bjl A:1-111 [20526]
        Other proteins in same PDB: d3bjla2, d3bjlb2
      2. 288291Domain d3bjlb1: 3bjl B:1-111 [20527]
        Other proteins in same PDB: d3bjla2, d3bjlb2
        VL dimer of Bence-Jones protein LOC
    6. Domains for 4bjl:
      1. 288292Domain d4bjla1: 4bjl A:1-111 [20528]
        Other proteins in same PDB: d4bjla2, d4bjlb2
      2. 288293Domain d4bjlb1: 4bjl B:1-111 [20529]
        Other proteins in same PDB: d4bjla2, d4bjlb2
        VL dimer of Bence-Jones protein LOC
  4. 288295Human (Homo sapiens), cluster 3.1 [TaxId:9606] [88537] (1 PDB entry)
  5. 288297Human (Homo sapiens), cluster 3.2 [TaxId:9606] [88538] (1 PDB entry)
  6. 288299Human (Homo sapiens), cluster 4 [TaxId:9606] [88539] (23 PDB entries)
    1. Domains for 1a8j:
      1. 288338Domain d1a8jh1: 1a8j H:1-111 [20598]
        Other proteins in same PDB: d1a8jh2, d1a8jl2
        part of the antibody MCG light chain dimer
        complexed with pme
      2. 288339Domain d1a8jl1: 1a8j L:1-111 [20597]
        Other proteins in same PDB: d1a8jh2, d1a8jl2
    2. Domains for 1dcl:
      1. 288306Domain d1dcla1: 1dcl A:1-111 [20565]
        Other proteins in same PDB: d1dcla2, d1dclb2
      2. 288307Domain d1dclb1: 1dcl B:1-111 [20566]
        Other proteins in same PDB: d1dcla2, d1dclb2
        part of the antibody MCG light chain dimer
    3. Domains for 1jvk:
      1. 288302Domain d1jvka1: 1jvk A:1-112 [71897]
        Other proteins in same PDB: d1jvka2, d1jvkb2
      2. 288303Domain d1jvkb1: 1jvk B:1-112 [71899]
        Other proteins in same PDB: d1jvka2, d1jvkb2
        part of amyloidogenic protein BUR
        complexed with pca
    4. Domains for 1lgv:
      1. 288300Domain d1lgva1: 1lgv A:1-112 [84608]
        Other proteins in same PDB: d1lgva2, d1lgvb2
      2. 288301Domain d1lgvb1: 1lgv B:1-112 [84610]
        Other proteins in same PDB: d1lgva2, d1lgvb2
        part of amyloidogenic protein BUR
        complexed with pca
    5. Domains for 1lhz:
      1. 288304Domain d1lhza1: 1lhz A:1-112 [84612]
        Other proteins in same PDB: d1lhza2, d1lhzb2
      2. 288305Domain d1lhzb1: 1lhz B:1-112 [84614]
        Other proteins in same PDB: d1lhza2, d1lhzb2
        part of amyloidogenic protein BUR
        complexed with pca
    6. Domains for 1mcb:
      1. 288316Domain d1mcba1: 1mcb A:1-111 [20575]
        Other proteins in same PDB: d1mcba2, d1mcbb2
      2. 288317Domain d1mcbb1: 1mcb B:1-111 [20576]
        Other proteins in same PDB: d1mcba2, d1mcbb2
        part of the antibody MCG light chain dimer
    7. Domains for 1mcc:
      1. 288324Domain d1mcca1: 1mcc A:1-111 [20583]
        Other proteins in same PDB: d1mcca2, d1mccb2
      2. 288325Domain d1mccb1: 1mcc B:1-111 [20584]
        Other proteins in same PDB: d1mcca2, d1mccb2
        part of the antibody MCG light chain dimer
        complexed with nh2
    8. Domains for 1mcd:
      1. 288312Domain d1mcda1: 1mcd A:1-111 [20571]
        Other proteins in same PDB: d1mcda2, d1mcdb2
      2. 288313Domain d1mcdb1: 1mcd B:1-111 [20572]
        Other proteins in same PDB: d1mcda2, d1mcdb2
        part of the antibody MCG light chain dimer
        complexed with bal, nh2
    9. Domains for 1mce:
      1. 288328Domain d1mcea1: 1mce A:1-111 [20587]
        Other proteins in same PDB: d1mcea2, d1mceb2
      2. 288329Domain d1mceb1: 1mce B:1-111 [20588]
        Other proteins in same PDB: d1mcea2, d1mceb2
        part of the antibody MCG light chain dimer
        complexed with bal
    10. Domains for 1mcf:
      1. 288318Domain d1mcfa1: 1mcf A:1-111 [20579]
        Other proteins in same PDB: d1mcfa2, d1mcfb2
      2. 288319Domain d1mcfb1: 1mcf B:1-111 [20580]
        Other proteins in same PDB: d1mcfa2, d1mcfb2
        part of the antibody MCG light chain dimer
        complexed with bal
    11. Domains for 1mch:
      1. 288340Domain d1mcha1: 1mch A:1-111 [20599]
        Other proteins in same PDB: d1mcha2, d1mchb2
      2. 288341Domain d1mchb1: 1mch B:1-111 [20600]
        Other proteins in same PDB: d1mcha2, d1mchb2
        part of the antibody MCG light chain dimer
        complexed with bal
    12. Domains for 1mci:
      1. 288320Domain d1mcia1: 1mci A:1-111 [20581]
        Other proteins in same PDB: d1mcia2, d1mcib2
      2. 288321Domain d1mcib1: 1mci B:1-111 [20582]
        Other proteins in same PDB: d1mcia2, d1mcib2
        part of the antibody MCG light chain dimer
    13. Domains for 1mcj:
      1. 288334Domain d1mcja1: 1mcj A:1-111 [20595]
        Other proteins in same PDB: d1mcja2, d1mcjb2
      2. 288335Domain d1mcjb1: 1mcj B:1-111 [20596]
        Other proteins in same PDB: d1mcja2, d1mcjb2
        part of the antibody MCG light chain dimer
        complexed with nh2
    14. Domains for 1mck:
      1. 288314Domain d1mcka1: 1mck A:1-111 [20573]
        Other proteins in same PDB: d1mcka2, d1mckb2
      2. 288315Domain d1mckb1: 1mck B:1-111 [20574]
        Other proteins in same PDB: d1mcka2, d1mckb2
        part of the antibody MCG light chain dimer
        complexed with nh2
    15. Domains for 1mcl:
      1. 288330Domain d1mcla1: 1mcl A:1-111 [20589]
        Other proteins in same PDB: d1mcla2, d1mclb2
      2. 288331Domain d1mclb1: 1mcl B:1-111 [20590]
        Other proteins in same PDB: d1mcla2, d1mclb2
        part of the antibody MCG light chain dimer
    16. Domains for 1mcn:
      1. 288332Domain d1mcna1: 1mcn A:1-111 [20591]
        Other proteins in same PDB: d1mcna2, d1mcnb2
      2. 288333Domain d1mcnb1: 1mcn B:1-111 [20592]
        Other proteins in same PDB: d1mcna2, d1mcnb2
        part of the antibody MCG light chain dimer
        complexed with nh2
    17. Domain for 1mco:
    18. Domains for 1mcq:
      1. 288322Domain d1mcqa1: 1mcq A:1-111 [20577]
        Other proteins in same PDB: d1mcqa2, d1mcqb2
      2. 288323Domain d1mcqb1: 1mcq B:1-111 [20578]
        Other proteins in same PDB: d1mcqa2, d1mcqb2
        part of the antibody MCG light chain dimer
        complexed with nh2
    19. Domains for 1mcr:
      1. 288336Domain d1mcra1: 1mcr A:1-111 [20593]
        Other proteins in same PDB: d1mcra2, d1mcrb2
      2. 288337Domain d1mcrb1: 1mcr B:1-111 [20594]
        Other proteins in same PDB: d1mcra2, d1mcrb2
        part of the antibody MCG light chain dimer
    20. Domains for 1mcs:
      1. 288326Domain d1mcsa1: 1mcs A:1-111 [20585]
        Other proteins in same PDB: d1mcsa2, d1mcsb2
      2. 288327Domain d1mcsb1: 1mcs B:1-111 [20586]
        Other proteins in same PDB: d1mcsa2, d1mcsb2
        part of the antibody MCG light chain dimer
    21. Domains for 1mcw:
      1. 288342Domain d1mcwm1: 1mcw M:1-111 [20601]
        Other proteins in same PDB: d1mcwm2, d1mcww2
      2. 288343Domain d1mcww1: 1mcw W:1-111 [20602]
        Other proteins in same PDB: d1mcwm2, d1mcww2
        part of heterologous L chain dimer MCG-WEIR
    22. Domains for 2mcg:
      1. 288308Domain d2mcg11: 2mcg 1:1-111 [20567]
        Other proteins in same PDB: d2mcg12, d2mcg22
      2. 288309Domain d2mcg21: 2mcg 2:1-111 [20568]
        Other proteins in same PDB: d2mcg12, d2mcg22
        part of the antibody MCG light chain dimer
    23. Domains for 3mcg:
      1. 288310Domain d3mcg11: 3mcg 1:1-111 [20569]
        Other proteins in same PDB: d3mcg12, d3mcg22
      2. 288311Domain d3mcg21: 3mcg 2:1-111 [20570]
        Other proteins in same PDB: d3mcg12, d3mcg22
        part of the antibody MCG light chain dimer
  7. 288345Human (Homo sapiens), cluster 5 [TaxId:9606] [88540] (3 PDB entries)
    1. Domain for 1adq:
    2. Domains for 1lil:
      1. 288348Domain d1lila1: 1lil A:2-107 [20557]
        Other proteins in same PDB: d1lila2, d1lilb2
      2. 288349Domain d1lilb1: 1lil B:2-107 [20558]
        Other proteins in same PDB: d1lila2, d1lilb2
        part of Bence-Jones protein CLE
    3. Domains for 8fab:
      1. 288346Domain d8faba1: 8fab A:3-105 [19772]
        Other proteins in same PDB: d8faba2, d8fabb1, d8fabb2, d8fabc2, d8fabd1, d8fabd2
      2. 288347Domain d8fabc1: 8fab C:3-105 [19774]
        Other proteins in same PDB: d8faba2, d8fabb1, d8fabb2, d8fabc2, d8fabd1, d8fabd2
        part of Fab HIL
  8. 288351Mouse (Mus musculus) [TaxId:10090] [88541] (25 PDB entries)
    1. Domain for 1a6u:
    2. Domains for 1a6v:
      1. 288364Domain d1a6vl_: 1a6v L: [20256]
        Other proteins in same PDB: d1a6vh_, d1a6vi_, d1a6vj_
      2. 288365Domain d1a6vm_: 1a6v M: [20258]
        Other proteins in same PDB: d1a6vh_, d1a6vi_, d1a6vj_
      3. 288366Domain d1a6vn_: 1a6v N: [20260]
        Other proteins in same PDB: d1a6vh_, d1a6vi_, d1a6vj_
        part of Fv B1-8
        complexed with npc
    3. Domain for 1a6w:
    4. Domain for 1dl7:
      • 288372Domain d1dl7l_: 1dl7 L: [20498]
        Other proteins in same PDB: d1dl7h_
        part of Fv M3C65; conflict: annotated in PDB as human protein
        complexed with nch
    5. Domains for 1etz:
      1. 288369Domain d1etza1: 1etz A:1-110 [20480]
        Other proteins in same PDB: d1etza2, d1etzb1, d1etzb2, d1etzh1, d1etzh2, d1etzl2
        part of anti-sweetener Fab NC10.14
        complexed with gas
      2. 288370Domain d1etzl1: 1etz L:1-110 [20478]
        Other proteins in same PDB: d1etza2, d1etzb1, d1etzb2, d1etzh1, d1etzh2, d1etzl2
    6. Domain for 1f4w:
    7. Domain for 1f4x:
    8. Domain for 1f4y:
    9. Domain for 1gig:
    10. Domain for 1ind:
    11. Domain for 1ine:
    12. Domain for 1jn6:
    13. Domains for 1jnh:
      1. 288373Domain d1jnha1: 1jnh A:1-108 [66939]
        Other proteins in same PDB: d1jnha2, d1jnhb1, d1jnhb2, d1jnhc2, d1jnhd1, d1jnhd2, d1jnhe2, d1jnhf1, d1jnhf2, d1jnhg2, d1jnhh1, d1jnhh2
      2. 288374Domain d1jnhc1: 1jnh C:1-108 [66943]
        Other proteins in same PDB: d1jnha2, d1jnhb1, d1jnhb2, d1jnhc2, d1jnhd1, d1jnhd2, d1jnhe2, d1jnhf1, d1jnhf2, d1jnhg2, d1jnhh1, d1jnhh2
      3. 288375Domain d1jnhe1: 1jnh E:1-108 [66947]
        Other proteins in same PDB: d1jnha2, d1jnhb1, d1jnhb2, d1jnhc2, d1jnhd1, d1jnhd2, d1jnhe2, d1jnhf1, d1jnhf2, d1jnhg2, d1jnhh1, d1jnhh2
      4. 288376Domain d1jnhg1: 1jnh G:1-108 [66951]
        Other proteins in same PDB: d1jnha2, d1jnhb1, d1jnhb2, d1jnhc2, d1jnhd1, d1jnhd2, d1jnhe2, d1jnhf1, d1jnhf2, d1jnhg2, d1jnhh1, d1jnhh2
        part of anti-estradiol Fab 10G6D6
        complexed with eco
    14. Domain for 1mfa:
    15. Domain for 1mfb:
    16. Domain for 1mfc:
    17. Domain for 1mfd:
    18. Domain for 1mfe:
    19. Domain for 1ngp:
    20. Domain for 1ngq:
    21. Domain for 1sm3:
    22. Domains for 1yuh:
      1. 288382Domain d1yuha1: 1yuh A:2-109 [20098]
        Other proteins in same PDB: d1yuha2, d1yuhb1, d1yuhb2, d1yuhh1, d1yuhh2, d1yuhl2
        part of an anti-nitrophenol Fab
        complexed with np
      2. 288383Domain d1yuhl1: 1yuh L:2-109 [20096]
        Other proteins in same PDB: d1yuha2, d1yuhb1, d1yuhb2, d1yuhh1, d1yuhh2, d1yuhl2
    23. Domain for 2vir:
    24. Domain for 2vis:
    25. Domain for 2vit:

More info for Protein Immunoglobulin light chain lambda variable domain, VL-lambda from b.1.1.1: V set domains (antibody variable domain-like)

Timeline for Protein Immunoglobulin light chain lambda variable domain, VL-lambda from b.1.1.1: V set domains (antibody variable domain-like):