Class b: All beta proteins [48724] (176 folds) |
Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies) sandwich; 7 strands in 2 sheets; greek-key some members of the fold have additional strands |
Superfamily b.1.1: Immunoglobulin [48726] (5 families) |
Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins) |
Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species) VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species |
Species Engineered (including hybrid species) [88533] (61 PDB entries) SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # Humanized antibody ! SQ NA # humanized antibody ! SQ NA # engineered antibody |
Domain d1ad9a1: 1ad9 A:1-107 [20214] Other proteins in same PDB: d1ad9a2, d1ad9b1, d1ad9b2, d1ad9h1, d1ad9h2, d1ad9l2 part of humanized Fab CTM01 complexed with so4 |
Domain d1ad9l1: 1ad9 L:1-107 [20212] Other proteins in same PDB: d1ad9a2, d1ad9b1, d1ad9b2, d1ad9h1, d1ad9h2, d1ad9l2 part of humanized Fab CTM01 complexed with so4 |
Domain d1b2wl1: 1b2w L:1-107 [20306] Other proteins in same PDB: d1b2wh1, d1b2wh2, d1b2wl2 part of a humanized anti-gamma-interferon Fab |
Domain d1bvka_: 1bvk A: [20278] Other proteins in same PDB: d1bvkb_, d1bvkc_, d1bvke_, d1bvkf_ part of humanized anti-lysozyme Fv HuLys11 |
Domain d1bvkd_: 1bvk D: [20280] Other proteins in same PDB: d1bvkb_, d1bvkc_, d1bvke_, d1bvkf_ part of humanized anti-lysozyme Fv HuLys11 |
Domain d1bvlb_: 1bvl B: [20283] Other proteins in same PDB: d1bvla_, d1bvlc_ part of humanized anti-lysozyme Fv HuLys11 |
Domain d1bvld_: 1bvl D: [20285] Other proteins in same PDB: d1bvla_, d1bvlc_ part of humanized anti-lysozyme Fv HuLys11 |
Domain d1fgvl_: 1fgv L: [19852] Other proteins in same PDB: d1fgvh_ part of humanized Fv H52 |
Domain d1fvca_: 1fvc A: [19862] Other proteins in same PDB: d1fvcb_, d1fvcd_ part of humanized Fv 4D5, herceptin |
Domain d1fvcc_: 1fvc C: [19864] Other proteins in same PDB: d1fvcb_, d1fvcd_ part of humanized Fv 4D5, herceptin |
Domain d1fvda1: 1fvd A:1-107 [19866] Other proteins in same PDB: d1fvda2, d1fvdb1, d1fvdb2, d1fvdc2, d1fvdd1, d1fvdd2 part of humanized Fab 4D5, herceptin |
Domain d1fvdc1: 1fvd C:1-107 [19868] Other proteins in same PDB: d1fvda2, d1fvdb1, d1fvdb2, d1fvdc2, d1fvdd1, d1fvdd2 part of humanized Fab 4D5, herceptin |
Domain d1fvea1: 1fve A:1-107 [19870] Other proteins in same PDB: d1fvea2, d1fveb1, d1fveb2, d1fvec2, d1fved1, d1fved2 part of humanized Fab 4D5, herceptin |
Domain d1fvec1: 1fve C:1-107 [19872] Other proteins in same PDB: d1fvea2, d1fveb1, d1fveb2, d1fvec2, d1fved1, d1fved2 part of humanized Fab 4D5, herceptin |
Domain d1i9rl1: 1i9r L:1-111 [71155] Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh1, d1i9rh2, d1i9rk1, d1i9rk2, d1i9rl2, d1i9rm2, d1i9rx1, d1i9rx2, d1i9ry2 part of humanized Fab 5C8 against C40 ligand complexed with zn |
Domain d1i9rm1: 1i9r M:1-111 [71157] Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh1, d1i9rh2, d1i9rk1, d1i9rk2, d1i9rl2, d1i9rm2, d1i9rx1, d1i9rx2, d1i9ry2 part of humanized Fab 5C8 against C40 ligand complexed with zn |
Domain d1i9ry1: 1i9r Y:1-111 [71161] Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh1, d1i9rh2, d1i9rk1, d1i9rk2, d1i9rl2, d1i9rm2, d1i9rx1, d1i9rx2, d1i9ry2 part of humanized Fab 5C8 against C40 ligand complexed with zn |
Domain d1it9l1: 1it9 L:1-111 [76785] Other proteins in same PDB: d1it9h1, d1it9h2, d1it9l2 part of humanized anti-human Fas Fab HFE7A |
Domain d1ivla_: 1ivl A: [20516] VL domain of synthetic antibody M29B; "reversed" dimerisation mode complexed with ipa |
Domain d1ivlb_: 1ivl B: [20517] VL domain of synthetic antibody M29B; "reversed" dimerisation mode complexed with ipa |
Domain d1jptl1: 1jpt L:1-107 [67053] Other proteins in same PDB: d1jpth1, d1jpth2, d1jptl2 part of humanized Fab D3H44 against human tissue factor |
Domain d1jv5a_: 1jv5 A: [67344] Other proteins in same PDB: d1jv5b_ part of an anti-blood group A Fv |
Domain d1l7il1: 1l7i L:1-107 [73658] Other proteins in same PDB: d1l7ih1, d1l7ih2, d1l7il2 part of humanized anti-ERBb2 Fab 2C4 complexed with so4 |
Domain d1mhpl1: 1mhp L:2-106 [84969] Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph1, d1mhph2, d1mhpl2, d1mhpx_ part of humanized anti-alpha1 integrin I-domain Fab complexed with mn |
Domain d1mhpy_: 1mhp Y: [84972] Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph1, d1mhph2, d1mhpl2, d1mhpx_ part of humanized anti-alpha1 integrin I-domain Fab; only V domain is ordered complexed with mn |
Domain d1op3k1: 1op3 K:2-107 [87210] Other proteins in same PDB: d1op3h1, d1op3h2, d1op3k2, d1op3l2, d1op3m1, d1op3m2 part of engineered Fab 2G12 complexed with bez, man |
Domain d1op3l1: 1op3 L:2-107 [87212] Other proteins in same PDB: d1op3h1, d1op3h2, d1op3k2, d1op3l2, d1op3m1, d1op3m2 part of engineered Fab 2G12 complexed with bez, man |
Domain d1op5k1: 1op5 K:2-107 [87218] Other proteins in same PDB: d1op5h1, d1op5h2, d1op5k2, d1op5l2, d1op5m1, d1op5m2 part of engineered Fab 2G12 complexed with man |
Domain d1op5l1: 1op5 L:2-107 [87220] Other proteins in same PDB: d1op5h1, d1op5h2, d1op5k2, d1op5l2, d1op5m1, d1op5m2 part of engineered Fab 2G12 complexed with man |
Domain d1pg7l1: 1pg7 L:1-107 [94678] Other proteins in same PDB: d1pg7h1, d1pg7h2, d1pg7i1, d1pg7i2, d1pg7l2, d1pg7m2, d1pg7w1, d1pg7w2, d1pg7x1, d1pg7x2, d1pg7y1, d1pg7y2, d1pg7z1, d1pg7z2 part of humanized Fab D3H44 against human tissue factor |
Domain d1pg7m1: 1pg7 M:1-107 [94680] Other proteins in same PDB: d1pg7h1, d1pg7h2, d1pg7i1, d1pg7i2, d1pg7l2, d1pg7m2, d1pg7w1, d1pg7w2, d1pg7x1, d1pg7x2, d1pg7y1, d1pg7y2, d1pg7z1, d1pg7z2 part of humanized Fab D3H44 against human tissue factor |
Domain d1rjla1: 1rjl A:1-107 [111821] Other proteins in same PDB: d1rjla2, d1rjlb1, d1rjlb2, d1rjlc_ MQ NA P01837 # artificial chimera |
Domain d1s3kh1: 1s3k H:1-119 [105237] Other proteins in same PDB: d1s3kh2, d1s3kl2 MQ NA P01857 # artificial chimera complexed with gol |
Domain d1s78c1: 1s78 C:1-107 [98624] Other proteins in same PDB: d1s78a1, d1s78a2, d1s78a3, d1s78a4, d1s78b1, d1s78b2, d1s78b3, d1s78b4, d1s78c2, d1s78d1, d1s78d2, d1s78e2, d1s78f1, d1s78f2 part of anti-ERBb2 Fab Pertuzumab complexed with nag |
Domain d1s78e1: 1s78 E:1-107 [98628] Other proteins in same PDB: d1s78a1, d1s78a2, d1s78a3, d1s78a4, d1s78b1, d1s78b2, d1s78b3, d1s78b4, d1s78c2, d1s78d1, d1s78d2, d1s78e2, d1s78f1, d1s78f2 part of anti-ERBb2 Fab Pertuzumab complexed with nag |
Domain d1t3fa1: 1t3f A:1-108 [112228] Other proteins in same PDB: d1t3fa2, d1t3fb1, d1t3fb2 |
Domain d1tjgl1: 1tjg L:1-107 [112448] Other proteins in same PDB: d1tjgh1, d1tjgh2, d1tjgl2 complexed with edo, ipa |
Domain d1tjhl1: 1tjh L:1-107 [112452] Other proteins in same PDB: d1tjhh1, d1tjhh2, d1tjhl2 complexed with edo, ipa |
Domain d1tjil1: 1tji L:1-107 [112456] Other proteins in same PDB: d1tjih1, d1tjih2, d1tjil2 complexed with edo, ipa |
Domain d1tzia1: 1tzi A:1-107 [107487] Other proteins in same PDB: d1tzia2, d1tzib1, d1tzib2, d1tziv_ |
Domain d1u8ha1: 1u8h A:1-107 [113128] Other proteins in same PDB: d1u8ha2, d1u8hb1, d1u8hb2 |
Domain d1u8ia1: 1u8i A:1-107 [113132] Other proteins in same PDB: d1u8ia2, d1u8ib1, d1u8ib2 |
Domain d1u8ja1: 1u8j A:1-107 [113136] Other proteins in same PDB: d1u8ja2, d1u8jb1, d1u8jb2 |
Domain d1u8ka1: 1u8k A:1-107 [113140] Other proteins in same PDB: d1u8ka2, d1u8kb1, d1u8kb2 |
Domain d1u8la1: 1u8l A:1-107 [113144] Other proteins in same PDB: d1u8la2, d1u8lb1, d1u8lb2 |
Domain d1u8ma1: 1u8m A:1-107 [113148] Other proteins in same PDB: d1u8ma2, d1u8mb1, d1u8mb2 |
Domain d1u8na1: 1u8n A:1-107 [113152] Other proteins in same PDB: d1u8na2, d1u8nb1, d1u8nb2 |
Domain d1u8oa1: 1u8o A:1-107 [113156] Other proteins in same PDB: d1u8oa2, d1u8ob1, d1u8ob2 |
Domain d1u8pa1: 1u8p A:1-107 [113160] Other proteins in same PDB: d1u8pa2, d1u8pb1, d1u8pb2 |
Domain d1u8qa1: 1u8q A:1-107 [113164] Other proteins in same PDB: d1u8qa2, d1u8qb1, d1u8qb2 |
Domain d1u91a1: 1u91 A:1-107 [113216] Other proteins in same PDB: d1u91a2, d1u91b1, d1u91b2 |
Domain d1u92a1: 1u92 A:1-107 [113220] Other proteins in same PDB: d1u92a2, d1u92b1, d1u92b2 |
Domain d1u93a1: 1u93 A:1-107 [113224] Other proteins in same PDB: d1u93a2, d1u93b1, d1u93b2 |
Domain d1u95a1: 1u95 A:1-107 [113228] Other proteins in same PDB: d1u95a2, d1u95b1, d1u95b2 |
Domain d2f5al1: 2f5a L:1-107 [88504] Other proteins in same PDB: d2f5ah1, d2f5ah2, d2f5al2 part of humanized HIV-1 neutralizing Fab 2F5 |
Domain d2f5bl1: 2f5b L:1-107 [88508] Other proteins in same PDB: d2f5bh1, d2f5bh2, d2f5bl2 part of humanized HIV-1 neutralizing Fab 2F5 |
Domain d2fgwl1: 2fgw L:1-108 [19854] Other proteins in same PDB: d2fgwh1, d2fgwh2, d2fgwl2 part of humanized Fab H52 |
Domain d2imna_: 2imn A: [19856] VL domain only of humanized antibody MCPC603 complexed with act, so4; mutant |
Domain d2pr4l1: 2pr4 L:1-107 [198259] Other proteins in same PDB: d2pr4h1, d2pr4h2, d2pr4l2 automated match to d2f5bl1 |
Domain d3idga1: 3idg A:1-107 [211576] Other proteins in same PDB: d3idga2 automated match to d2f5bl1 |
Domain d3idia1: 3idi A:1-107 [211580] Other proteins in same PDB: d3idia2 automated match to d2f5bl1 complexed with gol, so4 |
Domain d3idja1: 3idj A:1-107 [211582] Other proteins in same PDB: d3idja2 automated match to d2f5bl1 |
Domain d3idma1: 3idm A:1-107 [211584] Other proteins in same PDB: d3idma2 automated match to d2f5bl1 |
Domain d3idna1: 3idn A:1-107 [211586] Other proteins in same PDB: d3idna2 automated match to d2f5bl1 |
Domain d3levl1: 3lev L:1-107 [212860] Other proteins in same PDB: d3levh1, d3levh2, d3levl2 automated match to d1tjgl1 complexed with 1pe, atp, gol |
Domain d3oaul1: 3oau L:2-107 [214272] Other proteins in same PDB: d3oaul2 automated match to d1om3l1 complexed with gol, so4 |
Timeline for Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin light chain kappa variable domain, VL-kappa: