Lineage for Species: Engineered (including hybrid species)

  1. Root: SCOP 1.65
  2. 287094Class b: All beta proteins [48724] (126 folds)
  3. 287095Fold b.1: Immunoglobulin-like beta-sandwich [48725] (20 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 287096Superfamily b.1.1: Immunoglobulin [48726] (4 families) (S)
  5. 287097Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (21 proteins)
  6. 287738Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (14 species)
    VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogeneous CDRs are listed as engineered species
  7. 287739Species Engineered (including hybrid species) [88533] (25 PDB entries)

PDB entries in Species: Engineered (including hybrid species):

  1. Domain(s) for 1ad0:
    1. 287759Domain d1ad0a1: 1ad0 A:1-107 [20124]
      Other proteins in same PDB: d1ad0a2, d1ad0b1, d1ad0b2, d1ad0c2, d1ad0d1, d1ad0d2
    2. 287760Domain d1ad0c1: 1ad0 C:1-107 [20126]
      Other proteins in same PDB: d1ad0a2, d1ad0b1, d1ad0b2, d1ad0c2, d1ad0d1, d1ad0d2
      part of humanized Fab A5B7
  2. Domain(s) for 1ad9:
    1. 287766Domain d1ad9a1: 1ad9 A:1-107 [20214]
      Other proteins in same PDB: d1ad9a2, d1ad9b1, d1ad9b2, d1ad9h1, d1ad9h2, d1ad9l2
      part of humanized Fab CTM01
      complexed with so4
    2. 287767Domain d1ad9l1: 1ad9 L:1-107 [20212]
      Other proteins in same PDB: d1ad9a2, d1ad9b1, d1ad9b2, d1ad9h1, d1ad9h2, d1ad9l2
  3. Domain(s) for 1b2w:
  4. Domain(s) for 1bvk:
    1. 287770Domain d1bvka_: 1bvk A: [20278]
      Other proteins in same PDB: d1bvkb_, d1bvkc_, d1bvke_, d1bvkf_
    2. 287771Domain d1bvkd_: 1bvk D: [20280]
      Other proteins in same PDB: d1bvkb_, d1bvkc_, d1bvke_, d1bvkf_
      part of humanized anti-lysozyme Fv HuLys11
  5. Domain(s) for 1bvl:
    1. 287773Domain d1bvlb_: 1bvl B: [20283]
      Other proteins in same PDB: d1bvla_, d1bvlc_
    2. 287774Domain d1bvld_: 1bvl D: [20285]
      Other proteins in same PDB: d1bvla_, d1bvlc_
      part of humanized anti-lysozyme Fv HuLys11
  6. Domain(s) for 1fgv:
  7. Domain(s) for 1fvc:
    1. 287750Domain d1fvca_: 1fvc A: [19862]
      Other proteins in same PDB: d1fvcb_, d1fvcd_
    2. 287751Domain d1fvcc_: 1fvc C: [19864]
      Other proteins in same PDB: d1fvcb_, d1fvcd_
      part of humanized Fv 4D5, herceptin
  8. Domain(s) for 1fvd:
    1. 287757Domain d1fvda1: 1fvd A:1-107 [19866]
      Other proteins in same PDB: d1fvda2, d1fvdb1, d1fvdb2, d1fvdc2, d1fvdd1, d1fvdd2
    2. 287758Domain d1fvdc1: 1fvd C:1-107 [19868]
      Other proteins in same PDB: d1fvda2, d1fvdb1, d1fvdb2, d1fvdc2, d1fvdd1, d1fvdd2
      part of humanized Fab 4D5, herceptin
  9. Domain(s) for 1fve:
    1. 287761Domain d1fvea1: 1fve A:1-107 [19870]
      Other proteins in same PDB: d1fvea2, d1fveb1, d1fveb2, d1fvec2, d1fved1, d1fved2
    2. 287762Domain d1fvec1: 1fve C:1-107 [19872]
      Other proteins in same PDB: d1fvea2, d1fveb1, d1fveb2, d1fvec2, d1fved1, d1fved2
      part of humanized Fab 4D5, herceptin
  10. Domain(s) for 1gpo:
    1. 287747Domain d1gpol1: 1gpo L:1-112 [20224]
      Other proteins in same PDB: d1gpoh1, d1gpoh2, d1gpoi1, d1gpoi2, d1gpol2, d1gpom2
    2. 287748Domain d1gpom1: 1gpo M:1-112 [20226]
      Other proteins in same PDB: d1gpoh1, d1gpoh2, d1gpoi1, d1gpoi2, d1gpol2, d1gpom2
      complexed with so4
  11. Domain(s) for 1i9r:
    1. 287775Domain d1i9rl1: 1i9r L:1-111 [71155]
      Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh1, d1i9rh2, d1i9rk1, d1i9rk2, d1i9rl2, d1i9rm2, d1i9rx1, d1i9rx2, d1i9ry2
    2. 287776Domain d1i9rm1: 1i9r M:1-111 [71157]
      Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh1, d1i9rh2, d1i9rk1, d1i9rk2, d1i9rl2, d1i9rm2, d1i9rx1, d1i9rx2, d1i9ry2
    3. 287777Domain d1i9ry1: 1i9r Y:1-111 [71161]
      Other proteins in same PDB: d1i9ra_, d1i9rb_, d1i9rc_, d1i9rh1, d1i9rh2, d1i9rk1, d1i9rk2, d1i9rl2, d1i9rm2, d1i9rx1, d1i9rx2, d1i9ry2
      part of humanized Fab 5C8 against C40 ligand
      complexed with zn
  12. Domain(s) for 1it9:
  13. Domain(s) for 1ivl:
    1. 287753Domain d1ivla_: 1ivl A: [20516]
    2. 287754Domain d1ivlb_: 1ivl B: [20517]
      VL domain of synthetic antibody M29B; "reversed" dimerisation mode
      complexed with ipa
  14. Domain(s) for 1jps:
  15. Domain(s) for 1jpt:
  16. Domain(s) for 1l7i:
  17. Domain(s) for 1mhp:
    1. 287764Domain d1mhpl1: 1mhp L:2-106 [84969]
      Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph1, d1mhph2, d1mhpl2, d1mhpx_
      part of humanized anti-alpha1 integrin I-domain Fab
      complexed with mn; mutant
    2. 287765Domain d1mhpy_: 1mhp Y: [84972]
      Other proteins in same PDB: d1mhpa_, d1mhpb_, d1mhph1, d1mhph2, d1mhpl2, d1mhpx_
      part of humanized anti-alpha1 integrin I-domain Fab; only V domain is ordered
      complexed with mn; mutant
  18. Domain(s) for 1n8z:
  19. Domain(s) for 1om3:
    1. 287755Domain d1om3l1: 1om3 L:2-107 [87063]
      Other proteins in same PDB: d1om3h1, d1om3h2, d1om3k1, d1om3k2, d1om3l2, d1om3m2
    2. 287756Domain d1om3m1: 1om3 M:2-107 [87065]
      Other proteins in same PDB: d1om3h1, d1om3h2, d1om3k1, d1om3k2, d1om3l2, d1om3m2
      part of engineered Fab 2G12
  20. Domain(s) for 1op3:
    1. 287745Domain d1op3k1: 1op3 K:2-107 [87210]
      Other proteins in same PDB: d1op3h1, d1op3h2, d1op3k2, d1op3l2, d1op3m1, d1op3m2
    2. 287746Domain d1op3l1: 1op3 L:2-107 [87212]
      Other proteins in same PDB: d1op3h1, d1op3h2, d1op3k2, d1op3l2, d1op3m1, d1op3m2
      part of engineered Fab 2G12
      complexed with box, man
  21. Domain(s) for 1op5:
    1. 287778Domain d1op5k1: 1op5 K:2-107 [87218]
      Other proteins in same PDB: d1op5h1, d1op5h2, d1op5k2, d1op5l2, d1op5m1, d1op5m2
    2. 287779Domain d1op5l1: 1op5 L:2-107 [87220]
      Other proteins in same PDB: d1op5h1, d1op5h2, d1op5k2, d1op5l2, d1op5m1, d1op5m2
      part of engineered Fab 2G12
      complexed with man, nag
  22. Domain(s) for 2f5a:
  23. Domain(s) for 2f5b:
  24. Domain(s) for 2fgw:
  25. Domain(s) for 2imn:
    • 287742Domain d2imn__: 2imn - [19856]
      VL domain only of humanized antibody MCPC603
      complexed with ace, so4; mutant

More info for Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin light chain kappa variable domain, VL-kappa

Timeline for Species Engineered (including hybrid species) from b.1.1.1 Immunoglobulin light chain kappa variable domain, VL-kappa: