SCOP 1.75: Domain d1pf4a1: 1pf4 A:321-564

Lineage for d1pf4a1 (1pf4 A:321-564)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (24 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.12: ABC transporter ATPase domain-like [52686] (23 proteins)
   there are two additional subdomains inserted into the central core that has a RecA-like topology

6. Protein Multidrug resistance ABC transporter MsbA, C-terminal domain [89685] (2 species)
   a low-resolution structure of the E. coli MsbA in an open conformation is also available (f.35.1.1)
   a low-resolution structure of the E. coli MsbA in an open conformation is also available (f.35.1.1)

7. Species Vibrio cholerae [TaxId:666] [89686] (1 PDB entry)

8. Domain d1pf4a1: 1pf4 A:321-564 [88052]
   Other proteins in same PDB: d1pf4a2, d1pf4b2, d1pf4c2, d1pf4d2
   structure in a closed conformation

Details for d1pf4a1

PDB Entry: 1pf4, 3.8 Å

PDB Description: Structure of MsbA from Vibrio cholera: A Multidrug Resistance ABC Transporter Homolog in a Closed Conformation

PDB Compounds: (A:) transport ATP-binding protein MsbA

SCOP Domain Sequences for d1pf4a1:

Sequence; same for both SEQRES and ATOM records:

>d1pf4a1 c.37.1.12 (A:321-564) Multidrug resistance ABC transporter MsbA, C-terminal domain {Vibrio cholerae [TaxId: 666]}
lmdleterdngkyeaervngevdvkdvtftyqgkekpalshvsfsipqgktvalvgrsgs
gkstianlftrfydvdsgsicldghdvrdykltnlrrhfalvsqnvhlfndtianniaya
aegeytreqieqaarqahamefienmpqgldtvigengtslsggqrqrvaiarallrdap
vlildeatsaldteseraiqaaldelqknktvlviahrlstieqadeilvvdegeiierg
rhad

Timeline for d1pf4a1:

• d1pf4a1 first appeared in SCOP 1.65
  
• d1pf4a1 appears in SCOP 1.73
  
• d1pf4a1 does not appear in SCOPe 2.01