SCOPe 2.02: Domain d1p22a2: 1p22 A:253-545

Lineage for d1p22a2 (1p22 A:253-545)

1. Root: SCOPe 2.02

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.69: 7-bladed beta-propeller [50964] (14 superfamilies)
   consists of seven 4-stranded beta-sheet motifs; meander

4. Superfamily b.69.4: WD40 repeat-like [50978] (3 families)
   also contains 8-bladed propellers

5. Family b.69.4.1: WD40-repeat [50979] (11 proteins)
   this is a repeat family; one repeat unit is 1tyq C:201-243 found in domain

6. Protein F-box/WD-repeat protein 1 (beta-TRCP1) [89376] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89377] (1 PDB entry)

8. Domain d1p22a2: 1p22 A:253-545 [87716]
   Other proteins in same PDB: d1p22a1, d1p22b1, d1p22b2

Details for d1p22a2

PDB Entry: 1p22, 2.95 Å

PDB Description: Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity on the SCFbeta-TrCP1 ubiquitin ligase

PDB Compounds: (A:) F-box/WD-repeat protein 1A

SCOPe Domain Sequences for d1p22a2:

Sequence; same for both SEQRES and ATOM records:

>d1p22a2 b.69.4.1 (A:253-545) F-box/WD-repeat protein 1 (beta-TRCP1) {Human (Homo sapiens) [TaxId: 9606]}
grhslqrihcrsetskgvyclqyddqkivsglrdntikiwdkntleckriltghtgsvlc
lqyderviitgssdstvrvwdvntgemlntlihhceavlhlrfnngmmvtcskdrsiavw
dmasptditlrrvlvghraavnvvdfddkyivsasgdrtikvwntstcefvrtlnghkrg
iaclqyrdrlvvsgssdntirlwdiecgaclrvlegheelvrcirfdnkrivsgaydgki
kvwdlvaaldprapagtlclrtlvehsgrvfrlqfdefqivssshddtiliwd

Timeline for d1p22a2:

• d1p22a2 first appeared in SCOP 1.65
  
• d1p22a2 appears in SCOPe 2.01
  
• d1p22a2 appears in SCOPe 2.03
  
• d1p22a2 appears in the current release, SCOPe 2.08