SCOP 1.71: Domain d1oy0b_: 1oy0 B:

Lineage for d1oy0b_ (1oy0 B:)

1. Root: SCOP 1.71

2. Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (32 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.12: Phosphoenolpyruvate/pyruvate domain [51621] (6 families)

5. Family c.1.12.8: Ketopantoate hydroxymethyltransferase PanB [89503] (1 protein)

6. Protein Ketopantoate hydroxymethyltransferase PanB [89504] (3 species)
   dodecameric enzyme; a C-terminal helix exchange is observed in the M. tuberculosis enzyme but not in the E. coli enzyme

7. Species Mycobacterium tuberculosis [TaxId:1773] [89505] (1 PDB entry)

8. Domain d1oy0b_: 1oy0 B: [87544]

Details for d1oy0b_

PDB Entry: 1oy0, 2.8 Å

PDB Description: The crystal Structure of the First Enzyme of Pantothenate Biosynthetic Pathway, Ketopantoate Hydroxymethyltransferase from Mycobacterium Tuberculosis Shows a Decameric Assembly and Terminal Helix-Swapping

SCOP Domain Sequences for d1oy0b_:

Sequence, based on SEQRES records:

>d1oy0b_ c.1.12.8 (B:) Ketopantoate hydroxymethyltransferase PanB {Mycobacterium tuberculosis}
rtkirthhlqrwkadghkwamltaydystarifdeagipvllvgdsaanvvygydttvpi
sideliplvrgvvrgaphalvvadlpfgsyeagptaalaaatrflkdggahavklegger
vaeqiacltaagipvmahigftpqsvntlggfrvqgrgdaaeqtiadaiavaeagafavv
memvpaelatqitgkltiptvgigagpncdgqvlvwqdmagfsgaktarfvkryadvgge
lrraamqyaqevaggvfpadeh

Sequence, based on observed residues (ATOM records):

>d1oy0b_ c.1.12.8 (B:) Ketopantoate hydroxymethyltransferase PanB {Mycobacterium tuberculosis}
rtkirthhlqrwkadghkwamltaydystarifdeagipvllvgdsaanvvygydttvpi
sideliplvrgvvrgaphalvvadlpfgsyeagptaalaaatrflkdggahavklegger
vaeqiacltaagipvmahigftpgdaaeqtiadaiavaeagafavvmemvpaelatqitg
kltiptvgigagpncdgqvlvwqdmagfsgaktarfvkryadvggelrraamqyaqevag
gvfpadeh

Timeline for d1oy0b_:

• d1oy0b_ first appeared in SCOP 1.65
  
• d1oy0b_ appears in SCOP 1.69
  
• d1oy0b_ appears in SCOP 1.73
  
• d1oy0b_ appears in the current release, SCOPe 2.08