SCOP 1.71: Domain d1ox6a1: 1ox6 A:230-550

Lineage for d1ox6a1 (1ox6 A:230-550)

1. Root: SCOP 1.71

2. Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (32 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.2: Ribulose-phoshate binding barrel [51366] (5 families)

5. Family c.1.2.1: Histidine biosynthesis enzymes [51367] (2 proteins)
   structural evidence for the gene duplication within the barrel fold

6. Protein Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF [51370] (4 species)

7. Species Baker's yeast (Saccharomyces cerevisiae), His7 [TaxId:4932] [69379] (4 PDB entries)

8. Domain d1ox6a1: 1ox6 A:230-550 [87505]
   Other proteins in same PDB: d1ox6a2, d1ox6b2

Details for d1ox6a1

PDB Entry: 1ox6, 2.4 Å

PDB Description: towards understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerophosphate synthase

SCOP Domain Sequences for d1ox6a1:

Sequence, based on SEQRES records:

>d1ox6a1 c.1.2.1 (A:230-550) Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF {Baker's yeast (Saccharomyces cerevisiae), His7}
dysnygltrriiacldvrtndqgdlvvtkgdqydvreksdgkgvrnlgkpvqlaqkyyqq
gadevtflnitsfrdcplkdtpmlevlkqaaktvfvpltvgggikdivdvdgtkipalev
aslyfrsgadkvsigtdavyaaekyyelgnrgdgtspietiskaygaqavvisvdpkrvy
vnsqadtknkvfeteypgpngekycwyqctikggresrdlgvweltracealgageilln
cidkdgsnsgydleliehvkdavkipviassgagvpehfeeaflktradaclgagmfhrg
eftvndvkeyllehglkvrmd

Sequence, based on observed residues (ATOM records):

>d1ox6a1 c.1.2.1 (A:230-550) Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF {Baker's yeast (Saccharomyces cerevisiae), His7}
dysnygltrriiacldvrtndqgdlvvlgkpvqlaqkyyqqgadevtflnitdcplkdtp
mlevlkqaaktvfvpltvgggikdivdvdgtkipalevaslyfrsgadkvsigtdavyaa
ekyyelgnrgdgtspietiskaygaqavvisvdpkrvyvnsqadtknkvfeteypgpnge
kycwyqctikggresrdlgvweltracealgageillncidkdgsnsgydleliehvkda
vkipviassgagvpehfeeaflktradaclgagmfhrgeftvndvkeyllehglkvrmd

Timeline for d1ox6a1:

• d1ox6a1 first appeared in SCOP 1.65
  
• d1ox6a1 appears in SCOP 1.69
  
• d1ox6a1 appears in SCOP 1.73
  
• d1ox6a1 appears in the current release, SCOPe 2.08