SCOP 1.75: Domain d1op3m2: 1op3 M:116-228

Lineage for d1op3m2 (1op3 M:116-228)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (23 proteins)

6. Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88575] (172 PDB entries)
   Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3)
   SQ NA # humanized antibody
   Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region
   SQ NA # engineered antibody
   including humanized antibodies (chimeric proteins with human constant domains)
   Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody

8. Domain d1op3m2: 1op3 M:116-228 [87215]
   Other proteins in same PDB: d1op3h1, d1op3k1, d1op3k2, d1op3l1, d1op3l2, d1op3m1
   part of Fab 2G12
   complexed with box, man

Details for d1op3m2

PDB Entry: 1op3, 1.75 Å

PDB Description: crystal structure of fab 2g12 bound to man1->2man

PDB Compounds: (M:) FAB 2G12, heavy chain

SCOP Domain Sequences for d1op3m2:

Sequence; same for both SEQRES and ATOM records:

>d1op3m2 b.1.1.2 (M:116-228) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

Timeline for d1op3m2:

• d1op3m2 first appeared in SCOP 1.65
  
• d1op3m2 appears in SCOP 1.73
  
• d1op3m2 appears in SCOPe 2.01
  
• d1op3m2 last appears in SCOPe 2.07