SCOP 1.67: Domain d1ogsa2: 1ogs A:78-431

Lineage for d1ogsa2 (1ogs A:78-431)

1. Root: SCOP 1.67

2. Class c: Alpha and beta proteins (a/b) [51349] (130 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (28 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.8: (Trans)glycosidases [51445] (10 families)

5. Family c.1.8.3: beta-glycanases [51487] (22 proteins)
   consist of a number of sequence families

6. Protein Glucosylceramidase, catalytic domain [89473] (1 species)
   acid-beta-glucosidase; glycosyl hydrolase family 30; contains additional beta-domain similar to one found in alpha amylases

7. Species Human (Homo sapiens) [TaxId:9606] [89474] (1 PDB entry)

8. Domain d1ogsa2: 1ogs A:78-431 [86998]
   Other proteins in same PDB: d1ogsa1, d1ogsb1

Details for d1ogsa2

PDB Entry: 1ogs, 2 Å

PDB Description: human acid-beta-glucosidase

SCOP Domain Sequences for d1ogsa2:

Sequence; same for both SEQRES and ATOM records:

>d1ogsa2 c.1.8.3 (A:78-431) Glucosylceramidase, catalytic domain {Human (Homo sapiens)}
vkgfggamtdaaalnilalsppaqnlllksyfseegigyniirvpmascdfsirtytyad
tpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwtsptwlktngavngkgsl
kgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagllsgypfqclgftpehqr
dfiardlgptlansthhnvrllmlddqrlllphwakvvltdpeaakyvhgiavhwyldfl
apakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrgmqyshsiitnllyhvvg
wtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhlghfskfipegs

Timeline for d1ogsa2:

• d1ogsa2 first appeared in SCOP 1.65
  
• d1ogsa2 appears in SCOP 1.69
  
• d1ogsa2 appears in the current release, SCOPe 2.08