SCOP 1.67: Domain d1o0sb1: 1o0s B:296-593

Lineage for d1o0sb1 (1o0s B:296-593)

1. Root: SCOP 1.67

2. Class c: Alpha and beta proteins (a/b) [51349] (130 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (11 families)

5. Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (10 proteins)
   extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site

6. Protein Mitochondrial NAD(P)-dependent malic enzyme [51898] (3 species)
   includes C-terminal additional subdomains

7. Species Pig roundworm (Ascaris suum) [TaxId:6253] [75117] (2 PDB entries)

8. Domain d1o0sb1: 1o0s B:296-593 [86542]
   Other proteins in same PDB: d1o0sa2, d1o0sb2
   complexed with nai, ttn

Details for d1o0sb1

PDB Entry: 1o0s, 2 Å

PDB Description: crystal structure of ascaris suum malic enzyme complexed with nadh

SCOP Domain Sequences for d1o0sb1:

Sequence; same for both SEQRES and ATOM records:

>d1o0sb1 c.2.1.7 (B:296-593) Mitochondrial NAD(P)-dependent malic enzyme {Pig roundworm (Ascaris suum)}
iqgtasvivaglltctrvtkklvsqekylffgagaastgiaemivhqmqnegiskeeacn
riylmdidglvtknrkemnprhvqfakdmpettsileviraarpgaligastvrgafnee
viramaeinerpiifalsnptskaectaeeaytftngaalyasgspfpnfelnghtykpg
qgnnayifpgvalgtilfqirhvdndlfllaakkvascvtedslkvgrvypqlkeireis
iqiavemakycykngtanlypqpedlekyvraqvynteyeelinatydwpeqdmrhgf

Timeline for d1o0sb1:

• d1o0sb1 first appeared in SCOP 1.65
  
• d1o0sb1 appears in SCOP 1.69
  
• d1o0sb1 appears in the current release, SCOPe 2.08