SCOPe 2.06: Domain d1nyub_: 1nyu B:

Lineage for d1nyub_ (1nyu B:)

1. Root: SCOPe 2.06

2. Class g: Small proteins [56992] (94 folds)

3. Fold g.17: Cystine-knot cytokines [57500] (1 superfamily)
   disulfide-rich fold; common core is all-beta

4. Superfamily g.17.1: Cystine-knot cytokines [57501] (8 families)

5. Family g.17.1.2: Transforming growth factor (TGF)-beta [57507] (8 proteins)

6. Protein Activin A (Inhibin beta A) [90170] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [90171] (8 PDB entries)
   Uniprot P08476 311-426

8. Domain d1nyub_: 1nyu B: [86426]
   Other proteins in same PDB: d1nyua_, d1nyuc_
   complexed with the extracellular domain of activin type II receptor

Details for d1nyub_

PDB Entry: 1nyu, 3.1 Å

PDB Description: crystal structure of activin a bound to the ecd of actriib

PDB Compounds: (B:) Inhibin beta A chain

SCOPe Domain Sequences for d1nyub_:

Sequence, based on SEQRES records:

>d1nyub_ g.17.1.2 (B:) Activin A (Inhibin beta A) {Human (Homo sapiens) [TaxId: 9606]}
lecdgkvnicckkqffvsfkdigwndwiiapsgyhanycegecpshiagtsgsslsfhst
vinhyrmrghspfanlksccvptklrpmsmlyyddgqniikkdiqnmiveecgcs

Sequence, based on observed residues (ATOM records):

>d1nyub_ g.17.1.2 (B:) Activin A (Inhibin beta A) {Human (Homo sapiens) [TaxId: 9606]}
lecdgkvicckkqffvsfkdigwndwiiapsgyhanycegecpshilksccvptklrpms
mlyyddgqniikkdiqnmiveecgcs

Timeline for d1nyub_:

• d1nyub_ first appeared in SCOP 1.65
  
• d1nyub_ appears in SCOPe 2.05
  
• d1nyub_ appears in SCOPe 2.07
  
• d1nyub_ appears in the current release, SCOPe 2.08