SCOPe 2.06: Domain d1nvra_: 1nvr A:

Lineage for d1nvra_ (1nvr A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cell cycle checkpoint kinase chk1 [64404] (1 species)
   CaMK group; CAMKL subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [64405] (66 PDB entries)

8. Domain d1nvra_: 1nvr A: [86268]
   complex with peptide, chain B
   complexed with so4, stu

Details for d1nvra_

PDB Entry: 1nvr, 1.8 Å

PDB Description: The Complex Structure Of Checkpoint Kinase Chk1/Staurosporine

PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d1nvra_:

Sequence, based on SEQRES records:

>d1nvra_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
vpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkml
nhenvvkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylh
gigithrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrr
efhaepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplall
hkilvenpsaritipdikkdrwynkplkkga

Sequence, based on observed residues (ATOM records):

>d1nvra_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
vpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmknikkeicinkmlnhenvvk
fyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigithr
dikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepv
dvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilven
psaritipdikkdrwynkplkkga

Timeline for d1nvra_:

• d1nvra_ first appeared in SCOP 1.65
  
• d1nvra_ appears in SCOPe 2.05
  
• d1nvra_ appears in SCOPe 2.07
  
• d1nvra_ appears in the current release, SCOPe 2.08