SCOPe 2.05: Domain d1nowa2: 1now A:55-199

Lineage for d1nowa2 (1now A:55-199)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.2: beta-N-acetylhexosaminidase-like domain [55545] (4 families)
   contains similar fold but lacks its catalytic centre

5. Family d.92.2.1: beta-N-acetylhexosaminidase domain [55546] (4 proteins)
   family GH20

6. Protein beta-hexosaminidase B, N-terminal domain [89992] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89993] (6 PDB entries)

8. Domain d1nowa2: 1now A:55-199 [85937]
   Other proteins in same PDB: d1nowa1, d1nowb1
   complexed with gol, ifg, so4

Details for d1nowa2

PDB Entry: 1now, 2.2 Å

PDB Description: human lysosomal beta-hexosaminidase isoform b in complex with (2r,3r, 4s,5r)-2-acetamido-3,4-dihydroxy-5-hydroxymethyl-piperidinium chloride (galnac-isofagomine)

PDB Compounds: (A:) beta-hexosaminidase beta chain

SCOPe Domain Sequences for d1nowa2:

Sequence, based on SEQRES records:

>d1nowa2 d.92.2.1 (A:55-199) beta-hexosaminidase B, N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
alwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgfykwhhe
paefqaktqvqqllvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrglet
fsqlvyqdsygtftinestiidspr

Sequence, based on observed residues (ATOM records):

>d1nowa2 d.92.2.1 (A:55-199) beta-hexosaminidase B, N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
alwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgtqvqqll
vsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyqdsygtft
inestiidspr

Timeline for d1nowa2:

• d1nowa2 first appeared in SCOP 1.65
  
• d1nowa2 appears in SCOPe 2.04
  
• d1nowa2 appears in SCOPe 2.06
  
• d1nowa2 appears in the current release, SCOPe 2.08