SCOPe 2.08: Domain d1nmsb_: 1nms B:

Lineage for d1nmsb_ (1nms B:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.17: Caspase-like [52128] (1 superfamily)
   3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest

4. Superfamily c.17.1: Caspase-like [52129] (3 families)
   mature protein may be composed of two chains folded in a single domain

5. Family c.17.1.1: Caspase catalytic domain [52130] (8 proteins)

6. Protein Apopain (caspase-3, cpp32) [52131] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52132] (28 PDB entries)

8. Domain d1nmsb_: 1nms B: [85880]
   complexed with 161

Details for d1nmsb_

PDB Entry: 1nms, 1.7 Å

PDB Description: Caspase-3 tethered to irreversible inhibitor

PDB Compounds: (B:) Caspase-3

SCOPe Domain Sequences for d1nmsb_:

Sequence, based on SEQRES records:

>d1nmsb_ c.17.1.1 (B:) Apopain (caspase-3, cpp32) {Human (Homo sapiens) [TaxId: 9606]}
dnsykmdypemglciiinnknfhkstgmtsrsgtdvdaanlretfrnlkyevrnkndltr
eeivelmrdvskedhskrssfvcvllshgeegiifgtngpvdlkkitnffrgdrcrsltg
kpklfiiqacrgteldcgietdsgvdddmachkipvdadflyaystapgyyswrnskdgs
wfiqslcamlkqyadklefmhiltrvnrkvatefesfsfdatfhakkqipcivsmltkel
yfyh

Sequence, based on observed residues (ATOM records):

>d1nmsb_ c.17.1.1 (B:) Apopain (caspase-3, cpp32) {Human (Homo sapiens) [TaxId: 9606]}
dnsykmdypemglciiinnknfhkstgmtsrsgtdvdaanlretfrnlkyevrnkndltr
eeivelmrdvskedhskrssfvcvllshgeegiifgtngpvdlkkitnffrgdrcrsltg
kpklfiiqacrgteldcgietdddmachkipvdadflyaystapgyyswrnskdgswfiq
slcamlkqyadklefmhiltrvnrkvatefesfsfdatfhakkqipcivsmltkelyfyh

Timeline for d1nmsb_:

• d1nmsb_ first appeared in SCOP 1.65
  
• d1nmsb_ appears in SCOPe 2.07