SCOP 1.75: Domain d1ngxb1: 1ngx B:1-114

Lineage for d1ngxb1 (1ngx B:1-114)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (32 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88552] (152 PDB entries)
   Uniprot P01756 1-117 # 78% sequense identity; HV12_MOUSE Ig heavy chain V region MOPC 104E
   SQ NA # humanized antibody
   Uniprot P01750 # HV06_MOUSE Ig heavy chain V region 102 precursor
   Uniprot P01750 20-116 #
   HV06_MOUSE Ig heavy chain V region 102 precursor
   Uniprot P01756 1-117 # 78% sequense identity; HV12_MOUSE Ig heavy chain V region MOPC 104E ! SQ NA # humanized antibody ! Uniprot P01750 # HV06_MOUSE Ig heavy chain V region 102 precursor ! Uniprot P01750 20-116 # ! HV06_MOUSE Ig heavy chain V region 102 precursor

8. Domain d1ngxb1: 1ngx B:1-114 [85704]
   Other proteins in same PDB: d1ngxa1, d1ngxa2, d1ngxb2, d1ngxh2, d1ngxl1, d1ngxl2
   part of metal chelatase catalytic Fab 7G12; chimeric germline antibody

Details for d1ngxb1

PDB Entry: 1ngx, 1.8 Å

PDB Description: chimeric germline fab 7g12 with jeffamine fragment bound

PDB Compounds: (B:) Germline Metal Chelatase Catalytic Antibody, Heavy chain

SCOP Domain Sequences for d1ngxb1:

Sequence; same for both SEQRES and ATOM records:

>d1ngxb1 b.1.1.1 (B:1-114) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 3.2 [TaxId: 10090]}
qvqllesgaelvkpgasvklsckasgytftsywmhwvkqrpgrglewigridpnsggtky
nekfkskatltvdkpsstaymqlssltsedsavyyctrrdsdywgagttvtvss

Timeline for d1ngxb1:

• d1ngxb1 first appeared in SCOP 1.65
  
• d1ngxb1 appears in SCOP 1.73
  
• d1ngxb1 appears in SCOPe 2.01
  
• d1ngxb1 appears in the current release, SCOPe 2.08